Substituted 2-mercaptoquinoline-3-carboxamides as kcnq2/3 modulators

ABSTRACT

The invention relates to substituted 2-mercaptoquinoline-3-carboxamides, methods for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

The invention relates to substituted 2-mercaptoquinoline-3-carboxamides, methods for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.

The treatment of pain, in particular neuropathic pain, is of great importance in medicine. There is a worldwide need for effective pain therapies. The urgent need for action to find targeted, patient-appropriate treatment for chronic and non-chronic pain conditions, this being understood as the successful and satisfactory treatment of pain for the patient, is also documented in the large number of scientific works that have been published in recent times in the field of applied analgesics and basic research into nociception.

A pathophysiological feature of chronic pain is the overexcitability of neurons. Neuronal excitability is decisively influenced by the activity of K⁺ channels, since these significantly determine the resting potential of the cell and hence the excitability threshold. Heteromeric K⁺ channels of the molecular subtype KCNQ2/3 (Kv7.2/7.3) are expressed in neurons of various regions of the central (hippocampus, amygdala) and peripheral (dorsal root ganglia) nervous system and regulate the excitability thereof. Activation of KCNQ2/3 K⁺ channels leads to a hyperpolarisation of the cell membrane and, accompanying this, to a decrease in the electrical excitability of these neurons. KCNQ2/3-expressing neurons of the dorsal root ganglia are involved in the transmission of nociceptive stimuli from the periphery into the spinal cord (Passmore et al., J. Neurosci. 2003; 23(18):7227-36).

It has accordingly been possible to detect an analgesic activity in preclinical neuropathic and inflammatory pain models for the KCNQ2/3 agonist retigabine (Blackburn-Munro and Jensen, Eur J. Pharmacol. 2003; 460(2-3):109-16; post et al., Naunyn Schmiedeberg's Arch Pharmacol 2004; 369(4): 382-390).

The KCNQ2/3 K⁺ channel thus represents a suitable starting point for the treatment of pain; in particular pain chosen from the group consisting of chronic pain, neuropathic pain, inflammatory pain and muscular pain (Nielsen et al., Eur J. Pharmacol. 2004; 487(1-3): 93-103), in particular neuropathic and inflammatory pain.

Moreover, the KCNQ2/3 K⁺ channel is a suitable target for therapy of a large number of further diseases, such as, for example, migraine (US2002/0128277), cognitive diseases (Gribkoff, Expert Opin Ther Targets 2003; 7(6): 737-748), anxiety states (Korsgaard et al., J Pharmacol Exp Ther. 2005, 14(1): 282-92), epilepsy (Wickenden et al., Expert Opin Ther Pat 2004; 14(4): 457-469; Gribkoff, Expert Opin Ther Targets 2008, 12(5): 565-81; Miceli et al., Curr Opin Pharmacol 2008, 8(1): 65-74), urinary incontinence (Streng et al., J Urol 2004; 172: 2054-2058), dependency (Hansen et al., Eur J Pharmacol 2007, 570(1-3): 77-88), mania/bipolar disorders (Dencker et al., Epilepsy Behav 2008, 12(1): 49-53), dystonia-associated dyskinesias (Richter et al., Br J Pharmacol 2006, 149(6): 747-53).

There is a need for further compounds having comparable or better properties, not only in regard to affinity for KCNQ2/3 as such (potency, efficacy).

For instance, it can be advantageous to improve the metabolic stability, the solubility in aqueous media or the permeability of the compounds. These factors can have a beneficial effect on oral bioavailability or can alter the PK/PD (pharmacokinetic/pharmacodynamic) profile, which can lead to a more favourable period of action, for example.

A weak or non-existent interaction with transporter molecules, which are involved in the uptake and excretion of medicaments, can also be taken as an indication of improved bioavailability and at most low medicament interaction. Furthermore, interactions with the enzymes involved in the breakdown and excretion of medicaments should also be as low as possible, since such test results likewise indicate that at most low or even no medicament interactions whatsoever are to be anticipated.

It can further be advantageous if the compounds exhibit a high selectivity towards other receptors of the KCNQ family (specificity), for example towards KCNQ1, KCNQ3/5 or KCNQ4. A high selectivity can have a favourable effect on the side-effects profile. It is known, for example, that compounds which (also) bind to KCNQ1 are associated with a high risk of cardiac side effects, for which reason a high selectivity towards KCNQ1 can be desirable. A high selectivity towards other receptors can also be advantageous, however. A low affinity for the hERG ion channel or for the L-type calcium ion channel (phenyl alkylamine, benzothiazepine, dihydropyridine binding sites) can be advantageous, as these receptors are associated with the occurrence of cardiac side effects. Overall an improved selectivity with regard to binding to other endogenous proteins (i.e. receptors or enzymes for example) can lead to an improvement in the side-effects profile and hence to an improved compatibility.

An object of the invention was therefore to provide novel compounds having advantages over the prior art compounds. The compounds should in particular be suitable as pharmacological active ingredients in medicaments, preferably in medicaments for the treatment of disorders or diseases which are at least partly mediated by KCNQ2/3 K⁺ channels.

This object is achieved by the subject matter of the claims.

Substituted quinolinyl compounds are known from the prior art which are suitable as inhibitors of hYAK1 and hYAK3 kinases (WO 02/081728 A2). Furthermore 4-hydroxyquinoline-3-carboxylic acid derivatives are known as light stabilisers (EP 0 900 824 A1).

Surprisingly it has been found that substituted 2-mercaptoquinoline-3-carboxamides having the general formula (1) given below are suitable for the treatment of pain. It has further surprisingly been found that substituted 2-mercaptoquinoline-3-carboxamides having the general formula (1) given below also have an excellent affinity for the KCNQ2/3 K⁺ channel and are therefore suitable for the treatment of disorders or diseases which are at least partly mediated by KCNQ2/3 K⁺ channels.

The substituted 2-mercaptoquinoline-3-carboxamides act here as modulators, i.e. agonists or antagonists, of the KCNQ2/3 K⁺ channel.

The invention provides substituted 2-mercaptoquinoline-3-carboxamides having the general formula (1)

wherein R⁰ stands for C₁₋₁₀ alkyl or C₂₋₁₀ heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted; C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted, wherein the alkyl or heteroalkyl chain can in each case be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted, wherein the alkyl or heteroalkyl chain can in each case be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; R¹, R², R³, R⁴ each denote independently of one another H; F; Cl; Br; I; NO₂; OF₃; CN; R⁰; O(═O)H; C(═O)R⁰; CO₂H; C(═O)OR⁰; CONH₂; C(═O)NHR⁰; C(═O)N(R⁰)₂; OH; OR⁰; O—C(═O)—R⁰; O—C(═O)—O—R⁰; O—(C═O)—NH—R⁰; O—C(═O)—N(R⁰)₂; O—S(═O)₂—R⁰; O—S(═O)₂OH; O—S(═O)₂OR⁰; O—S(═O)₂NH₂; O—S(═O)₂NHR⁰; O—S(═O)₂N(R⁰)₂; NH₂; NH—R⁰; N(R⁰)₂; NH—C(═O)—R⁰; NH—C(═O)—O—R⁰; NH—C(═O)—N(R⁰)₂; NH—C(═O)—NH—R⁰; NH—C(═O)—N(R⁰)₂; NR⁰—C(═O)—R⁰; NR⁰—C(═O)—O—R⁰; NR⁰—C(═O)—NH₂; NR⁰—C(═O)—NH—R⁰; NR⁰—C(═O)—N(R⁰)₂; NH—S(═O)₂OH; NH—S(═O)₂R⁰; NH—S(═O)₂OR⁰; NH—S(═O)₂NH₂; NH—S(═O)₂NHR⁰; NH—S(═O)₂N(R)₂; NR⁰—S(═O)₂OH; NR⁰—S(═O)₂R⁰; NR⁰—S(═O)₂OR⁰; NR⁰—S(═O)₂NH₂; NR⁰—S(═O)₂NHR⁰; NR⁰—S(═O)₂N(R⁰)₂; SH; SR⁰; S(═O)₂R⁰; S(═O)₂R⁰; S(═O)₂OH; S(═O)₂OR⁰; S(═O)₂NH₂; S(═O)₂NHR⁰; or S(═O)₂N(R)₂; R⁵ stands for H; F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)H; C(═O)R⁰; CO₂H; C(═O)OR⁰; CONH₂; C(═O)NHR⁰; C(═O)N(R⁰)₂; OR⁰; O—C(═O)—R⁰; O—C(═O)—O—R⁰; O—(C═O)—NH—R⁰; O—C(═O)—N(R⁰)₂; O—S(═O)₂R⁰; O—S(═O)₂OH; O—S(═O)₂R⁰; O—S(═O)₂NH₂; O—S(═O)₂NHR⁰; O—S(═O)₂N(R⁰)₂; NH₂; NH—R⁰; N(R⁰)₂; NH—C(═O)—R⁰; NH—C(═O)—O—R⁰; NH—C(═O)—NH₂; NH—C(═O)—NH—R⁰; NH—C(═O)—N(R⁰)₂; NR⁰—C(═O)—R⁰; NR⁰—C(═O)—O—R⁰; NR⁰—C(═O)—NH₂; NR⁰—C(═O)—NH—R⁰; NR⁰—C(═O)—N(R⁰)₂; NH—S(═O)₂OH; NH—S(═O)₂R⁰; NH—S(═O)₂OR⁰; NH—S(═O)₂NH₂; NH—S(═O)₂NHR⁰; NH—S(═O)₂N(R)₂; NR⁰—S(═O)₂OH; NR⁰—S(═O)₂R⁰; NR⁰—S(═O)₂OR⁰; NR⁰—S(═O)₂NH₂; NR⁰—S(═O)₂NHR⁰; NR⁰—S(═O)₂N(R⁰)₂; SH; SR⁰; S(═O)R⁰; S(═O)₂R⁰; S(═O)₂OH; S(═O)₂OR⁰; S(═O)₂NH₂; S(═O)₂NHR⁰; or S(═O)₂N(R)₂; R⁶ stands for R⁰, with the proviso that if R⁰ denotes heterocyclyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted, or heteroaryl, unsubstituted or mono- or polysubstituted, then the binding of the heteroaryl or heterocyclyl is made via a carbon atom of the heteroaryl or heterocyclyl; R⁷ stands for R⁰, with the proviso that if R⁰ denotes heterocyclyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted, or heteroaryl, unsubstituted or mono- or polysubstituted, then the binding of the heteroaryl or heterocyclyl is made via a carbon atom of the heteroaryl or heterocyclyl; wherein “alkyl substituted”, “heteroalkyl substituted”, “heterocyclyl substituted” and “cycloalkyl substituted” stands for the substitution of one or more hydrogen atoms, each independently of one another, with F; Cl; Br; I; CN; CF₃; ═O; =NH; ═C(NH₂)₂; NO₂; R⁰; C(═O)H; C(═O)H; C(═O)R⁰; CO₂H; C(═O)OR⁰; CONH₂; C(═O)NHR⁰; C(═O)N(R)₂; OH; OR⁰; —O—(C₁₋₈ alkyl)-O—; O—C(═O)—R⁰; O—C(═O)—O—R⁰; O—(C═O)—NH—R⁰; O—C(═O)—N(R⁰)₂; O—S(═O)₂—R⁰; O—S(═O)₂OH; O—S(═O)₂R⁰; O—S(═O)₂NH₂; O—S(═O)₂NHR⁰; O—S(═O)₂N(R⁰)₂; NH₂; NH—R⁰; N(R⁰)₂; NH—C(═O)—R⁰; NH—C(═O)—O—R⁰; NH—C(═O)—NH₂; NH—C(═O)—NH—R⁰; NH—C(═O)—N(R⁰)₂; NR⁰—C(═O)—R⁰; NR⁰—C(═O)—O—R⁰; NR⁰—C(═O)—NH₂; NR⁰—C(═O)—NH—R⁰; NR⁰—C(═O)—N(R⁰)₂; NH—S(═O)₂OH; NH—S(═O)₂R⁰; NH—S(═O)₂OR⁰; NH—S(═O)₂NH₂; NH—S(═O)₂NHR⁰; NH—S(═O)₂N(R)₂; NR⁰—S(═O)₂OH; NR⁰—S(═O)₂R⁰; NR⁰—S(═O)₂OR⁰; NR⁰—S(═O)₂NH₂; NR⁰—S(═O)₂NHR⁰; NR⁰—S(═O)₂N(R⁰)₂; SH; SR⁰; S(═O)R⁰; S(═O)₂R⁰; S(═O)₂H; S(═O)₂OH; S(═O)₂OR⁰; S(═O)₂NH₂; S(═O)₂NHR⁰; S(═O)₂N(R⁰)₂; wherein “aryl substituted” and “heteroaryl substituted” stands for the substitution of one or more hydrogen atoms, each independently of one another, with F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)H; C(═O)R⁰; CO₂H; C(═O)OR⁰; CONH₂; C(═O)NHR⁰; C(═O)N(R⁰)₂; OH; OR⁰; —O—(C₁₋₈ alkyl)-O—; O—C(═O)—R⁰; O—C(═O)—O—R⁰; O—(C═O)—NH—R⁰; O—C(═O)—N(R⁰)₂; O—S(═O)₂—R⁰; O—S(═O)₂OH; O—S(═O)₂OR⁰; O—S(═O)₂NH₂; O—S(═O)₂NHR⁰; O—S(═O)₂N(R⁰)₂; NH₂; NH—R⁰; N(R⁰)₂; NH—C(═O)—R⁰; NH—C(═O)—O—R⁰; NH—C(═O)—NH₂; NH—C(═O)—NH—R⁰; NH—C(═O)—N(R⁰)₂; NR⁰—C(═O)—R⁰; NR⁰—C(═O)—O—R⁰; NR⁰—C(═O)—NH₂; NR⁰—C(═O)—NH—R⁰; NR⁰—C(═O)—N(R⁰)₂; NH—S(═O)₂OH; NH—S(═O)₂R⁰; NH—S(═O)₂OR⁰; NH—S(═O)₂NH₂; NH—S(═O)₂NHR⁰; NH—S(═O)₂N(R)₂; NR⁰—S(═O)₂OH; NR⁰—S(═O)₂R⁰; NR⁰—S(═O)₂OR⁰; NR⁰—S(═O)₂NH₂; NR⁰—S(═O)₂NHR⁰; NR⁰—S(═O)₂N(R⁰)₂; SH; SR⁰; S(═O)R⁰; S(═O)₂R⁰; S(═O)₂OH; S(═O)₂OR⁰; S(═O)₂NH₂; S(═O)₂NHR⁰; S(═O)₂N(R⁰)₂; with the exception of the following compound:

-   N-benzyl-2-(3-chloro-2-hydroxypropylthio)-4-(2,4-dichlorophenyl)quinoline-3-carboxamide;

in the form of the free compounds or salts of physiologically compatible acids or bases.

Within the meaning of this invention the expressions “alkyl” or “C₁₋₁₀ alkyl”, “C₁₋₈ alkyl” and “C₁₋₄ alkyl” include acyclic saturated or unsaturated aliphatic hydrocarbon radicals, which can be branched or unbranched and unsubstituted or mono- or polysubstituted, having respectively 1 to 10 or 1 to 8 or 1 to 4 C atoms, i.e. C₁₋₁₀ alkanyls, C₂₋₁₀ alkenyls and C₂₋₁₀ alkynyls or C₁₋₈ alkanyls, C₂₋₈ alkenyls and C₂₋₈ alkynyls or C₁₋₄ alkanyls, C₂₋₄ alkenyls and C₂₋₄ alkynyls. Alkenyls have at least one C—C double bond and alkynyls have at least one C—C triple bond. Alkyl is preferably selected from the group comprising methyl, ethyl, n-propyl, 2-propyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, n-heptyl, n-octyl, n-nonyl, n-decyl, ethenyl (vinyl), ethynyl, propenyl (—CH₂CH═CH₂, —CH═CH—CH₃, —C(═CH₂)—CH₃), propynyl (—CH—C≡CH, —C≡C—CH₃), butenyl, butynyl, pentenyl, pentynyl, hexenyl and hexynyl, heptenyl, heptynyl, octenyl, octynyl, nonenyl, nonynyl, decenyl and decynyl.

Within the meaning of this invention the expressions “heteroalkyl” or “C₂₋₁₀ heteroalkyl” and “C₂₋₈ heteroalkyl” include acyclic aliphatic saturated or unsaturated hydrocarbon radicals having 2 to 10 C atoms, i.e. C₂₋₁₀ heteroalkanyls, C₂₋₁₀ heteroalkenyls and C₂₋₁₀ heteroalkynyls, or having 2 to 8 C atoms, i.e. C₂₋₈ heteroalkanyls, C₂₋₈ heteroalkenyls and C₂₋₈ heteroalkynyls, which can each be branched or unbranched and unsubstituted or mono- or polysubstituted and in which at least one, optionally also two or three carbon atoms are replaced by a heteroatom or a heteroatom group selected independently of one another from the group consisting of O, S, S(═O), S(═O)₂, N, NH, and N(C₁₋₈ alkyl), preferably N(CH₃), wherein the initial carbon atom of a C₂₋₁₀ heteroalkyl or a C₂₋₈ heteroalkyl via which the C₂₋₁₀ heteroalkyl or the C₂₋₈ heteroalkyl is bound to the higher-order general structure cannot be replaced by a heteroatom or a heteroatom group and adjacent carbon atoms cannot simultaneously be replaced by a heteroatom or a heteroatom group. The heteroatom groups NH and N(C₁₋₈ alkyl) of the heteroalkyl can optionally be mono- or polysubstituted. C₂₋₁₀ heteroalkenyls and C₂₋₈ heteroalkenyls have at least one C—C or one C—N double bond and C₂₋₁₀ heteroalkynyls and C₂₋₈ heteroalkynyls have at least one C—C triple bond. Heteroalkyl is preferably selected from the group comprising —CH₂—O—CH₃, —CH₂—CH₂—O—CH₃, —CH₂—CH₂—O—CH₂—CH₃, —CH₂—CH₂—O—CH₂—CH₂—O—CH₃, —CH═CH—O—CH₃, —CH═CH—O—CH₂—CH₃, ═CH—O—CH₃, ═CH—O—CH₂—CH₃, ═CH—CH₂—O—CH₂—CH₃, ═CH—CH₂—O—CH₃, —CH₂—NH—CH₃, —CH₂—CH₂—NH—CH₃, —CH₂—CH₂—NH—CH₂—CH₃, —CH₂—CH₂—NH—CH₂—CH₂—NH—CH₃, —CH═CH—NH—CH₃, —CH═CH—NH—CH₂—CH₃, —CH═CH—N(CH₃)—CH₂—CH₃, ═CH—NH—CH₃, ═CH—NH—CH₂—CH₃, ═CH—CH₂—NH—CH₂—CH₃, ═CH—CH₂—NH—CH₃, —CH₂—N(CH₃)—CH₃, —CH₂—CH₂—N(CH₃)—CH₃, —CH₂—CH₂—N(CH₃)—CH₂—CH₃, —CH₂—CH₂—N(CH₃)—CH₂—CH₂—N(CH₃)—CH₃, CH₂—CH₂—NH—CH₂—CH₂—O—CH₃, CH₂—CH₂—O—CH₂—CH₂—NH—CH₃, CH₂—CH₂—N(CH₃)—CH₂—CH₂—O—CH₃, CH₂—CH₂—O—CH₂—CH₂—N(CH₃)—CH₃, CH₂—NH—CH₂—O—CH₃, CH₂—O—CH₂—NH—CH₃, CH₂—N(CH₃)—CH₂—O—CH₃, CH₂—O—CH₂—N(CH₃)—CH₃, —CH═CH—N(CH₃)—CH₃, ═CH—N(CH₃)—CH₃, ═CH—N(CH₃)—CH₂—CH₃, ═CH—CH₂—N(CH₃)—CH₂—CH₃, ═CH—CH₂—N(CH₃)—CH₃, —CH₂—CH₂═N(CH₃) and —CH₂═N(CH₃).

For the purposes of this invention the expression “cycloalkyl” or “C₃₋₁₀ cycloalkyl” denotes cyclic aliphatic hydrocarbons having 3, 4, 5, 6, 7, 8, 9 or 10 carbon atoms, wherein the hydrocarbons can be saturated or unsaturated (but not aromatic), unsubstituted or mono- or polysubstituted. The binding of the cycloalkyl to the higher-order general structure can be made via any desired and possible ring member of the cycloalkyl radical. The cycloalkyl radicals can also be fused to further saturated, (partially) unsaturated, (hetero)cyclic, aromatic or heteroaromatic ring systems, i.e. to cycloalkyl, heterocyclyl, aryl or heteroaryl, which can in turn be unsubstituted or mono- or polysubstituted. The cycloalkyl radicals can further be singly or multiply bridged, as for example in the case of adamantyl, bicyclo[2.2.1]heptyl or bicyclo[2.2.2]octyl. Cycloalkyl is preferably selected from the group comprising cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, cyclononyl,

cyclodecyl, adamantyl, cyclopentenyl, cyclohexenyl, cycloheptenyl and cyclooctenyl.

The term “heterocyclyl” or “heterocycloalkyl” includes aliphatic saturated or unsaturated (but not aromatic) cycloalkyls having three to ten, i.e. 3, 4, 5, 6, 7, 8, 9 or 10 ring members, in which at least one, optionally also two or three, carbon atoms are replaced by a heteroatom or a heteroatom group selected independently of one another from the group consisting of O, S, N, NH and N(C₁₋₈ alkyl), preferably N(CH₃), wherein the ring members can be unsubstituted or mono- or polysubstituted. The binding of the heterocyclyl to the higher-order general structure can be made via any desired and possible ring member of the heterocyclyl radical. The heterocyclyl radicals can also be fused to further saturated, (partially) unsaturated, (hetero)cyclic or aromatic or heteroaromatic ring systems, i.e. to cycloalkyl, heterocyclyl, aryl or heteroaryl, which can in turn be unsubstituted or mono- or polysubstituted. Preferred are heterocyclyl radicals from the group comprising azetidinyl, aziridinyl, azepanyl, azocanyl, diazepanyl, dithiolanyl, dihydroquinolinyl, dihydropyrrolyl, dioxanyl, dioxolanyl, dihydroindenyl, dihydropyridinyl, dihydrofuranyl, dihydroisoquinolinyl, dihydroindolinyl, dihydroisoindolyl, imidazolidinyl, isoxazolidinyl, morpholinyl, oxiranyl, oxetanyl, pyrrolidinyl, piperazinyl, piperidinyl, pyrazolidinyl, pyranyl, tetrahydropyrrolyl, tetrahydropyranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl, tetrahydroindolinyl, tetrahydrofuranyl, tetrahydropyridinyl, tetrahydrothiophenyl, tetrahydropyridoindolyl, tetrahydronaphthyl, tetrahydrocarbolinyl, tetrahydroisoxazolopyridinyl, thiazolidinyl and thiomorpholinyl.

Within the meaning of this invention, the term “aryl” denotes aromatic hydrocarbons having up to 14 ring members, inter alia phenyls and naphthyls. Each aryl radical can be present in unsubstituted or mono- or polysubstituted form, wherein the aryl substituents can be identical or different and can be at any desired and possible position of the aryl. The binding of the aryl to the higher-order general structure can be made via any desired and possible ring member of the aryl radical. The aryl radicals can also be fused to further saturated, (partially) unsaturated, (hetero)cyclic, aromatic or heteroaromatic ring systems, i.e. to cycloalkyl, heterocyclyl, aryl or heteroaryl, which can in turn be unsubstituted or mono- or polysubstituted. Examples of fused aryl radicals are benzodioxolanyl and benzodioxanyl. Aryl is preferably selected from the group including phenyl, 1-naphthyl and 2-naphthyl, each of which can be unsubstituted or mono- or polysubstituted. A particularly preferred aryl is phenyl, unsubstituted or mono- or polysubstituted.

The term “heteroaryl” stands for a 5- or 6-membered cyclic aromatic radical containing at least 1, optionally also 2, 3, 4 or 5 heteroatoms, wherein the heteroatoms can each be selected independently of one another from the group S, N and O and the heteroaryl radical can be unsubstituted or mono- or polysubstituted; if the heteroaryl is substituted, the substituents can be identical or different and can be at any desired and possible position of the heteroaryl. The binding to the higher-order general structure can be made via any desired and possible ring member of the heteroaryl radical. The heteroaryl can also be part of a bicyclic or polycyclic system having up to 14 ring members, wherein the ring system can be formed with further saturated, (partially) unsaturated, (hetero)cyclic or aromatic or heteroaromatic rings, i.e. with cycloalkyl, heterocyclyl, aryl or heteroaryl, which can in turn be unsubstituted or mono- or polysubstituted. The heteroaryl radical is preferably selected from the group comprising benzofuranyl, benzoimidazolyl, benzothienyl, benzothiadiazolyl, benzothiazolyl, benzotriazolyl, benzooxazolyl, benzooxadiazolyl, quinazolinyl, quinoxalinyl, carbazolyl, quinolinyl, dibenzofuranyl, dibenzothienyl, furyl (furanyl), imidazolyl, imidazothiazolyl, indazolyl, indolizinyl, indolyl, isoquinolinyl, isoxazolyl, isothiazolyl, indolyl, naphthyridinyl, oxazolyl, oxadiazolyl, phenazinyl, phenothiazinyl, phthalazinyl, pyrazolyl, pyridyl (2-pyridyl, 3-pyridyl, 4-pyridyl), pyrrolyl, pyridazinyl, pyrimidinyl, pyrazinyl, purinyl, phenazinyl, thienyl (thiophenyl), triazolyl, tetrazolyl, thiazolyl, thiadiazolyl or triazinyl. Furyl, pyridyl and thienyl are particularly preferred.

Within the meaning of the invention the expressions “C₁₋₄ alkyl- or C₁₋₈ alkyl-bridged aryl, heteroaryl, heterocyclyl or cycloalkyl” mean that C₁₋₄ alkyl or C₁₋₈ alkyl and aryl or heteroaryl or heterocyclyl or cycloalkyl have the meanings defined above and the aryl or heteroaryl or heterocyclyl or cycloalkyl radical is bound by a C₁₋₄ alkyl or a C₁₋₈ alkyl group to the higher-order general structure. The alkyl chain can in all cases be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted. C₁₋₄ alkyl or C₁₋₈ alkyl are preferably selected from the group comprising —CH₂—, —CH₂—CH₂—, —CH(CH₃)—, —CH₂—CH₂—CH₂—, —CH(CH₃)—CH₂₋₃—CH(CH₂CH₃)—, —CH₂—(CH₂)₂—CH₂—, —CH(CH₃)—CH₂—CH₂—, —CH₂—CH(CH₃)—CH₂₋₃—CH(CH₃)—CH(CH₃)—, —CH(CH₂CH₃)—CH₂—, —C(CH₃)₂—CH₂—, —CH(CH₂CH₂CH₃)—, —C(CH₃)(CH₂CH₃)—, —CH₂—(CH₂)₃—CH₂—, —CH(CH₃)—CH₂—CH₂—CH₂—, —CH₂—CH(CH₃)—CH₂—CH₂—, —CH(CH₃)—CH₂—CH(CH₃)—, —CH(CH₃)—CH(CH₃)—CH₂—, —C(CH₃)₂—CH₂—CH₂, —CH₂—C(CH₃)₂—CH₂—, —CH(CH₂CH₃)—CH₂—CH₂—, —CH₂—CH(CH₂CH₃)—CH₂₋₃—O(CH₃)₂—CH(CH₃)—, —CH(CH₂CH₃)—CH(CH₃)—, —C(CH₃)(CH₂CH₃)—CH₂—, —CH(CH₂CH₂CH₃)—CH₂—, —C(CH₂CH₂CH₃)—CH₂—, —CH(CH₂CH₂CH₂CH₃)—, —(CH₃)(CH₂CH₂CH₃)—, —C(CH₂CH₃)₂—, —CH₂—(CH₂)₄—CH₂—, —CH═CH—, —CH═CH—CH₂—, —C(CH₃)═CH₂—, —CH═CH—CH₂—CH₂₋₃—CH₂—CH═CH—CH₂—, —CH═CH—CH═CH—, —C(CH₃)═CH—CH₂—, —CH═C(CH₃)—CH₂₋₃—C(CH₃)═C(CH₃)—, —C(CH₂CH₃)═CH—, —CH═CH—CH₂—CH₂—CH₂—, —CH₂—CH═CH₂—CH₂—CH₂—, —CH═CH═CH—CH₂—CH₂—, —CH═CH₂—CH—CH═CH₂—, —C≡C—, —C≡C—CH₂—, —C≡C—CH₂—CH₂—, —C≡C—CH(CH₃)—, —CH₂—C≡C—CH₂—, —C≡C—C≡C—, —C≡C—C(CH₃)₂—, —C≡C—CH₂—CH₂—CH₂—, —CH₂—C≡C—CH₂—CH₂—, —C≡C—C≡C—CH₂— and —C≡C—CH₂—C≡C—.

Within the meaning of the invention the expressions “C₂₋₈ heteroalkyl-bridged aryl, heteroaryl, heterocyclyl or cycloalkyl” mean that C₂₋₈ heteroalkyl and aryl or heteroaryl or heterocyclyl or cycloalkyl have the meanings defined above and the aryl or heteroaryl or heterocyclyl or cycloalkyl radical is bound by a C₂₋₈ heteroalkyl group to the higher-order general structure. The heteroalkyl chain can in all cases be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted. If a terminal carbon atom of the C₂₋₈ heteroalkyl group is replaced by a heteroatom or a heteroatom group, the binding of a heteroaryl or a heterocyclyl to the heteroatom or the heteroatom group of the C₂₋₈ heteroalkyl is always made via a carbon atom of the heteroaryl or heterocyclyl. The terminal carbon atom is understood to mean the carbon atom within the C₂₋₈ heteroalkyl which within the chain is the furthest away from the general higher-order structure. If the terminal carbon atom of a C₂₋₈ heteroalkyl is replaced by an N(CH₃) group, for example, this is the furthest away from the general higher-order structure within the C₂₋₈ heteroalkyl and bound to the aryl or heteroaryl or heterocyclyl or cycloalkyl radical. C₂₋₈ heteroalkyl is preferably selected from the group comprising —CH₂—NH—, —CH₂—N(CH₃)—, —CH₂—O—, —CH₂—CH₂—NH—, —CH₂—CH₂—N(CH₃)—, —CH₂—CH₂—O—, —CH₂—CH₂—CH₂—NH—, —CH₂—CH₂—CH₂—N(CH₃)—, —CH₂—CH₂—CH₂—O—, —CH₂—O—CH₂—, —CH₂—CH₂—O—CH₂—, —CH₂—CH₂—O—CH₂—CH₂—, —CH₂—CH₂—O—CH₂—CH₂—O—CH₂—, —CH═CH—O—CH₂—, —CH═CH—O—CH₂—CH₂—, ═CH—O—CH₂—, ═CH—O—CH₂—CH₂—, ═CH—CH₂—O—CH₂—CH₂—, ═CH—CH₂—O—CH₂—, —CH₂—NH—CH₂—, —CH₂—CH₂—NH—CH₂—, —CH₂—CH₂—NH—CH₂—CH₂—, —CH₂—CH₂—NH—CH₂—CH₂—NH—CH₂, —CH═CH—NH—CH₂—, —CH═CH—NH—CH₂—CH₂—, —CH═CH—N(CH₃)—CH₂—CH₂—, ═CH—NH—CH₂—, ═CH—NH—CH₂—CH₂—, ═CH—CH₂—NH—CH₂—CH₂—, ═CH—CH₂—NH—CH₂—, —CH₂—N(CH₃)—CH₂—, —CH₂—CH₂—N(CH₃)—CH₂—, —CH₂—CH₂—N(CH₃)—CH₂—CH₂—, —CH₂—CH₂—N(CH₃)—CH₂—CH₂—N(CH₃)—CH₂—, —CH₂—CH₂—NH—CH₂—CH₂—O—CH₂—, —CH₂—CH₂—O—CH₂—CH₂—NH—CH₂—, —CH₂—CH₂—N(CH₃)—CH₂—CH₂—O—CH₂—, —CH₂—CH₂—O—CH₂—CH₂—N(CH₃)—CH₂—, —CH₂—NH—CH₂—O—CH₂—, —CH₂—O—CH₂—NH—CH₂—, —CH₂—N(CH₃)—CH₂—O—CH₂—, —CH₂—O—CH₂—N(CH₃)—CH₂—, —CH═CH—N(CH₃)—CH₂—, ═CH—N(CH₃)—CH₂—, ═CH—N(CH₃)—CH₂—CH₂—, ═CH—CH₂—N(CH₃)—CH₂—CH₂—, ═CH—CH₂—N(CH₃)—CH₂—, —CH₂—S—, —CH₂—CH₂—S—, —CH₂—CH₂—CH₂—S—, —CH₂—CH₂—CH₂—CH₂—S—, —CH₂—S(═O)₂—, —CH₂—CH₂—S(═O)₂—, —CH₂—CH₂—CH₂—S(═O)₂— and —CH₂—CH₂—CH₂—CH₂—S(═O)₂—.

In connection with “alkyl”, “heteroalkyl”, “heterocyclyl” and “cycloalkyl” the term “mono- or polysubstituted” within the meaning of this invention is understood to mean the single or multiple, e.g. two, three or four times, substitution of one or more hydrogen atoms, each independently of one another, with substituents selected from the group comprising F; Cl; Br; I; CN; CF₃; ═O; =NH; ═C(NH₂)₂; NO₂; R⁰; C(═O)H; C(═O)R⁰; CO₂H; C(═O)OR⁰; CONH₂; C(═O)NHR⁰; C(═O)N(R⁰)₂; OH; OR⁰; —O—(C₁₋₈ alkyl)-O—; O—C(═O)—R⁰; O—C(═O)—O—R⁰; O—(C═O)—NH—R⁰; O—C(═O)—N(R)₂; O—S(═O)₂—R⁰; O—S(═O)₂OH; O—S(═O)₂OR⁰; O—S(═O)₂NH₂; O—S(═O)₂NHR⁰; O—S(═O)₂N(R⁰)₂; NH₂; NH—R⁰; N(R⁰)₂; NH—C(═O)—R⁰; NH—C(═O)—O—R⁰; NH—C(═O)—NH₂; NH—C(═O)—NH—R⁰; NH—C(═O)—N(R⁰)₂; NR⁰—C(═O)—R⁰; NR⁰—C(═O)—O—R⁰; NR⁰—C(═O)—NH₂; NR⁰—C(═O)—NH—R⁰; NR⁰—C(═O)—N(R⁰)₂; NH—S(═O)₂OH; NH—S(═O)₂R⁰; NH—S(═O)₂OR⁰; NH—S(═O)₂NH₂; NH—S(═O)₂NHR⁰; NH—S(═O)₂N(R)₂; NR⁰—S(═O)₂OH; NR⁰—S(═O)₂R⁰; NR⁰—S(═O)₂OR⁰; NR⁰—S(═O)₂NH₂; NR⁰—S(═O)₂NHR⁰; NR⁰—S(═O)₂N(R⁰)₂; SH; SR⁰; S(═O)R⁰; S(═O)₂R⁰; S(═O)₂OH; S(═O)₂OR⁰; S(═O)₂N(R⁰)₂; S(═O)₂NHR⁰; S(═O)₂N(R⁰)₂, wherein polysubstituted radicals are understood to be radicals which are substituted multiple times, for example twice, three or four times, at different or the same atoms, for example substituted three times at the same C atom, as in the case of CF₃ or CH₂CF₃, or at different points, as in the case of CH(OH)—CH═CH—CHCl₂. A substituent can in turn itself optionally be mono- or polysubstituted. The polysubstitution can be performed with identical or different substituents.

Preferred “alkyl”, “heteroalkyl”, “heterocyclyl” and “cycloalkyl” substituents are selected from the group comprising F; Cl; Br; I; NO₂; CF₃; CN; ═O; ═NH; R⁰; C(═O)(R⁰ or H); C(═O)O(R⁰ or H); C(═O)N(R⁰ or H)₂; OH; OR⁰; O—C(═O)—R⁰; O—(C₁₋₈ alkyl)-OH; O—(C₁₋₈ alkyl)-O—C₁₋₈ alkyl; OCF₃; N(R⁰ or H)₂; N(R⁰ or H)—C(═O)—R⁰; N(R⁰ or H)—C(═O)—N(R⁰ or H)₂; SH; SCF₃; SR⁰; S(═O)₂R⁰; S(═O)₂O(R⁰ or H) and S(═O)₂—N(R⁰ or H)₂.

Particularly preferred “alkyl”, “heteroalkyl”, “heterocyclyl” and “cycloalkyl” substituents are selected from the group consisting of F; Cl; Br; I; NO₂; CF₃; CN; ═O; C₁₋₈ alkyl; C₂₋₈ heteroalkyl; aryl; heteroaryl; C₃₋₁₀ cycloalkyl; heterocyclyl; C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged aryl, heteroaryl, C₃₋₁₀ cycloalkyl or heterocyclyl; CHO; C(═O)C₁₋₈ alkyl; C(═O) aryl; C(═O) heteroaryl; CO₂H; C(═O)O—C₁₋₈ alkyl; C(═O)O— aryl; C(═O)O-heteroaryl; CONH₂; C(═O)NH—C₁₋₈ alkyl; C(═O)N(C₁₋₈ alkyl)₂; C(═O)NH-aryl; C(═O)N(aryl)₂; C(═O)NH-heteroaryl; C(═O)N(heteroaryl)₂; C(═O)N(C₁₋₈ alkyl)(aryl); C(═O)N(C₁₋₈ alkyl)(heteroaryl); C(═O)N(heteroaryl)(aryl); OH; O—C₁₋₈ alkyl; OCF₃; O—(C₁₋₈ alkyl)-OH; O—(C₁₋₈ alkyl)-O—C₁₋₈ alkyl; O-benzyl; O-aryl; O-heteroaryl; O—C(═O)C₁₋₈ alkyl; O—C(═O) aryl; O—C(═O) heteroaryl; NH₂; NH—C₁₋₈ alkyl; N(C₁₋₈ alkyl)₂; NH—C(═O)C₁₋₈ alkyl; N(C₁₋₈ alkyl)-C(═O)C₁₋₈ alkyl; N(C(═O)C₁₋₈ alkyl)₂; NH—C(═O)-aryl; NH—C(═O)-heteroaryl; SH; S—C₁₋₈ alkyl; SCF₃; S-benzyl; S-aryl; S-heteroaryl; S(═O)₂C₁₋₈ alkyl; S(═O)₂ aryl; S(═O)₂ heteroaryl; S(═O)₂OH; S(═O)₂O—C₁₋₈ alkyl; S(═O)₂O-aryl; S(═O)₂O-heteroaryl; S(═O)₂—NH—C₁₋₈ alkyl; S(═O)₂—NH-aryl; and S(═O)₂—NH—C₁₋₈ heteroaryl.

In connection with “aryl” and “heteroaryl” the expression “mono- or polysubstituted” within the meaning of this invention is understood to mean the single or multiple, e.g. two, three or four times, substitution of one or more hydrogen atoms in the ring system, each independently of one another, with substituents selected from the group comprising F; Cl; Br; I; NO₂; CF₃; CN; R⁰; O(═O)H; C(═O)R⁰; CO₂H; C(═O)OR⁰; CONH₂; C(═O)NHR⁰; C(═O)N(R⁰)₂; OH; OR⁰; O—C(═O)—R⁰; O—C(═O)—O—R⁰; O—(C═O)—NH—R⁰; O—C(═O)—N(R⁰)₂; O—S(═O)₂—R⁰; O—S(═O)₂OH; O—S(═O)₂OR⁰; O—S(═O)₂NH₂; O—S(═O)₂NHR⁰; O—S(═O)₂N(R⁰)₂; NH₂; NH—R⁰; N(R⁰)₂; NH—C(═O)—R⁰; NH—C(═O)—O—R⁰; NH—C(═O)—NH₂; NH—C(═O)—NH—R⁰; NH—C(═O)—N(R⁰)₂; NR⁰—C(═O)—R⁰; NR⁰—C(═O)—O—R⁰; NR⁰—C(═O)—NH₂; NR⁰—C(═O)—NH—R⁰; NR⁰—C(═O)—N(R⁰)₂; NH—S(═O)₂OH; NH—S(═O)₂R⁰; NH—S(═O)₂OR⁰; NH—S(═O)₂NH₂; NH—S(═O)₂NHR⁰; NH—S(═O)₂N(R⁰)₂; NR⁰—S(═O)₂OH; NR⁰—S(═O)₂R⁰; NR⁰—S(═O)₂OR⁰; NR⁰—S(═O)₂N(R⁰)₂; NR⁰—S(═O)₂NHR⁰; NR⁰—S(═O)₂N(R⁰)₂; SH; SR⁰; S(═O)R⁰; S(═O)₂R⁰; S(═O)₂OH; S(═O)₂OR⁰; S(═O)₂NH₂; S(═O)₂NHR⁰; S(═O)₂N(R⁰)₂, at one or optionally different atoms, wherein a substituent can in turn itself optionally be mono- or polysubstituted. The polysubstitution is performed with identical or with different substituents.

Preferred “aryl” and “heteroaryl” substituents are F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)(R⁰ or H); C(═O)O(R⁰ or H); C(═O)N(R⁰ or H)₂; OH; OR⁰; O—C(═O)—R⁰; O—(C₁₋₈ alkyl)-O—C₁₋₈ alkyl; OCF₃; N(R⁰ or H)₂; N(R⁰ or H)—C(═O)—R⁰; N(R⁰ or H)—C(═O)—N(R⁰ or H)₂; SH; SCF₃; SR⁰; S(═O)₂R⁰; S(═O)₂O(R⁰ or H); S(═O)₂—N(R⁰ or H)₂.

Particularly preferred “aryl” and “heteroaryl” substituents are selected from the group consisting of F; Cl; Br; I; NO₂; CF₃; CN; C₁₋₈ alkyl; or C₂₋₈ heteroalkyl; aryl; heteroaryl; C₃₋₁₀ cycloalkyl; heterocyclyl; C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged aryl, heteroaryl, C₃₋₁₀ cycloalkyl or heterocyclyl; CHO; C(═O)C₁₋₈ alkyl; C(═O) aryl; C(═O) heteroaryl; CO₂H; C(═O)—O—C₁₋₈ alkyl; C(═O)O-aryl; C(═O)O-heteroaryl; CONH₂; C(═O)NH—C₁₋₈ alkyl; C(═O)N(C₁₋₈ alkyl)₂; C(═O)NH-aryl; C(═O)N(aryl)₂; C(═O)NH-heteroaryl; C(═O)N(heteroaryl)₂; C(═O)N(C₁₋₈ alkyl)(aryl); C(═O)N(C₁₋₈ alkyl)(heteroaryl); C(═O)N(heteroaryl)(aryl); OH; O—C₁₋₈ alkyl; OCF₃; O—(C₁₋₈ alkyl)-OH; O—(C₁₋₈ alkyl)-O—C₁₋₈ alkyl; O-benzyl; O-aryl; O-heteroaryl; O—C(═O)C₁₋₈ alkyl; O—C(═O)aryl; O—C(═O)heteroaryl; NH₂; NH—C₁₋₈ alkyl; N(C₁₋₈ alkyl)₂; NH—C(═O)C₁₋₈ alkyl; N(C₁₋₈ alkyl)-C(═O)C₁₋₈ alkyl; N(C(═O)C₁₋₈ alkyl)₂; NH—C(═O)-aryl; NH—C(═O)-heteroaryl; SH; S—C₁₋₈ alkyl; SCF₃; S-benzyl; S-aryl; S-heteroaryl; S(═O)₂C₁₋₈ alkyl; S(═O)₂ aryl; S(═O)₂ heteroaryl; S(═O)₂OH; S(═O)₂O—C₁₋₈ alkyl; S(═O)₂O-aryl; S(═O)₂O-heteroaryl; S(═O)₂—NH—C₁₋₈ alkyl; S(═O)₂—NH-aryl; S(═O)₂—NH—C₁₋₈ heteroaryl.

The compounds according to the invention are defined by substituents, for example by R¹, R² and R³ (1^(st) generation substituents), which are in turn optionally substituted (2^(nd) generation substituents). Depending on the definition, these substituents of the substituents can themselves be substituted again (3^(rd) generation substituents). For example, if R³═R⁰ where R⁰=aryl (1^(st) generation substituent), then aryl can itself be substituted, e.g. with NHR⁰, where R⁰═C₁₋₁₀ alkyl (2^(nd) generation substituent). This gives the functional group aryl-NHC₁₋₁₀, alkyl. C₁₋₁₀ alkyl can then itself be substituted again, for example with Cl (3^(rd) generation substituent). This then gives in total the functional group aryl-NHC₁₋₁₀ alkyl-Cl.

In a preferred embodiment the 3^(rd) generation substituents cannot, however, be substituted again, i.e. there are then no 4^(th) generation substituents.

In another preferred embodiment the 2^(nd) generation substituents cannot be substituted again, i.e. there are then no 3^(rd) generation substituents either. In other words, in this embodiment for example in the case of the general formula (1) the functional groups for R⁰ to R⁷ can each optionally be substituted, but the various substituents cannot then themselves be substituted again.

If a radical occurs more than once within a molecule, such as the radical R⁰ for example, then this radical can have different meanings for different substituents: for example, if both R¹═R⁰ and R²═R⁰, then R⁰ can stand for R¹=aryl and R⁰ can stand for R²═C₁₋₁₀ alkyl.

In some cases the compounds according to the invention are defined by substituents which are or which carry an aryl or heteroaryl radical, each unsubstituted or mono- or polysubstituted, or which together with the carbon atom(s) or heteroatom(s) binding them as ring member or ring members form a ring, for example an aryl or heteroaryl, each unsubstituted or mono- or polysubstituted. Both these aryl or heteroaryl radicals and the aromatic ring systems formed in this way can optionally be fused to C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, i.e. to a C₃₋₁₀ cycloalkyl such as cyclopentyl or to a heterocyclyl such as morpholinyl, wherein the C₃₋₁₀ cycloalkyl or heterocyclyl radicals fused in this way can themselves be unsubstituted or mono- or polysubstituted.

In some cases the compounds according to the invention are defined by substituents which are or which carry a C₃₋₁₀ cycloalkyl or heterocyclyl radical, each unsubstituted or mono- or polysubstituted, or which together with the carbon atom(s) or heteroatom(s) binding them as ring member or ring members form a ring, for example a C₃₋₁₀ cycloalkyl or heterocyclyl, each unsubstituted or mono- or polysubstituted. Both these C₃₋₁₀ cycloalkyl or heterocyclyl radicals and the aliphatic ring systems formed can optionally be fused to aryl or heteroaryl, i.e. to an aryl such as phenyl or to a heteroaryl such as pyridyl, wherein the aryl or heteroaryl radicals fused in this way can themselves be unsubstituted or mono- or polysubstituted.

In some cases the compounds according to the invention are defined by radicals within which two substituents are referred to by the general expression “(“substituent 1” or “substituent 2” or “substituent 3”)”. This expression means that “substituent 1” and “substituent 2” and “substituent 3” within such a radical can occur in any possible combination. Thus for example the expression “(R⁰ or H)” within a radical means that R⁰ and H can occur within this radical in any possible combination. Thus the radical “N(R⁰ or H)₂” can stand for “NH₂”, “NHR⁰” and)“N(R⁰)₂”, for example. If R⁰ occurs more than once within a radical, as in the case of)“N(R⁰)₂”, then R⁰ can have the same or different meanings in each case: in the present example of)“N(R⁰)₂”, for example, R⁰ can stand twice for aryl, giving the functional group “N(aryl)₂”, or R⁰ can stand once for aryl and once for C₁₋₁₀ alkyl, giving the functional group “N(aryl)(C₁₋₁₀ alkyl)”.

In the context of the present invention, the symbol

used in formulae represents a linking of a corresponding radical to the higher-order general structure.

Within the meaning of this invention the term “salt formed with a physiologically compatible acid” is understood to mean salts of the individual active ingredient with inorganic or organic acids which are physiologically—particularly when used in humans and/or mammals—compatible. Hydrochloride is particularly preferred.

Examples of physiologically compatible acids are: hydrochloric acid, hydrobromic acid, sulfuric acid, methanesulfonic acid, formic acid, acetic acid, oxalic acid, succinic acid, tartaric acid, mandelic acid, fumaric acid, maleic acid, lactic acid, citric acid, glutamic acid, saccharinic acid, monomethyl sebacic acid, 5-oxoproline, hexane-1-sulfonic acid, nicotinic acid, 2-, 3- or 4-aminobenzoic acid, 2,4,6-trimethylbenzoic acid, α-lipoic acid, acetylglycine, hippuric acid, phosphoric acid and/or aspartic acid. Citric acid and hydrochloric acid are particularly preferred.

Physiologically compatible salts with cations or bases are salts of the individual compound as anion with at least one, preferably inorganic, cation, which are physiologically—particularly when used in humans and/or mammals—compatible. Particularly preferred are the salts of the alkali and alkaline-earth metals, but also ammonium salts, but in particular (mono) or (di)sodium, (mono) or (di)potassium, magnesium or calcium salts.

In a preferred embodiment of the compounds according to the invention the substituents R¹, R², R³ and R⁴ are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)(R⁰ or H); C(═O)O(R⁰ or H); C(═O)N(R⁰ or H)₂; OH; OR⁰; O—(C₁₋₈ alkyl)-OH; O—(C₁₋₈ alkyl)-O—C₁₋₈ alkyl; OCF₃; O—C(═O)—R⁰; N(R⁰ or H)₂; N(R⁰ or H)—C(═O)—R⁰; N(R⁰ or H)—C(═O)—N(R⁰ or H)₂; SH; SCF₃; SR⁰; S(═O)₂R⁰; S(═O)₂O(R⁰ or H) and S(═O)₂—N(R⁰ or H)₂.

The substituents R¹, R², R³ and R⁴ are preferably each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; C(═O)H; C(═O)—OH; C(═O)NH₂; C₁₋₈ alkyl, O—C₁₋₈ alkyl, C(═O)C₁₋₈ alkyl, C(═O)—O—C₁₋₈ alkyl, O—C(═O)—C₁₋₈ alkyl, C(═O)NH—C₁₋₈ alkyl, C(═O)N(C₁₋₈ alkyl)₂, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, NH—C(═O)C₁₋₈ alkyl, N(C₁₋₈ alkyl)-C(═O)C₁₋₈ alkyl, S—C₁₋₈ alkyl, S(═O)₂C₁₋₈ alkyl, S(═O)₂O—C₁₋₈ alkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O-methyl and OH; OH; OCF₃; SH; SCF₃; S(═O)₂OH; NH₂; C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted; benzyl, phenyl, pyridyl or thienyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, NH₂, CN, C₁₋₈ alkyl, O—C₁₋₈ alkyl, CF₃, OH, OCF₃, C(═O)—OH, SCF₃ and S(═O)₂OH.

The substituents R¹, R², R³ and R⁴ are particularly preferably each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; CH₂CF₃; C(═O)—OH; C(═O)NH₂; SH; SCF₃; S(═O)₂OH; NH₂; OCF₃; OH; C₁₋₈ alkyl, O—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, each saturated, branched or unbranched, unsubstituted or mono-, di- or trisubstituted with one, two or three substituents selected independently of one another from the group consisting of O-methyl and OH; C(═O)C₁₋₈ alkyl, C(═O)O—C₁₋₈ alkyl, O—C(═O)—C₁₋₈ alkyl, C(═O)NH—C₁₋₈ alkyl, C(═O)N(C₁₋₈ alkyl)₂, NH—C(═O)C₁₋₈ alkyl, N(C₁₋₈ alkyl)-0(═O)C₁₋₈ alkyl, N(C(═O)C₁₋₈ alkyl)₂, S—C₁₋₈ alkyl, S(═O)₂O—C₁₋₈ alkyl, each saturated, branched or unbranched, unsubstituted; C₃₋₁₀ cycloalkyl, saturated, unsubstituted; pyrrolidinyl, piperidinyl, 4-methylpiperazinyl, piperazinyl or morpholinyl, each unsubstituted; benzyl, phenyl or pyridyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents selected independently of one another from the group consisting of F, Cl, Br, I, CN, C₁₋₈ alkyl, O—C₁₋₈ alkyl, CF₃, OH and OCF₃.

The substituents R¹, R², R³ and R⁴ are most particularly preferably each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; methyl; ethyl; n-propyl; isopropyl; cyclopropyl; n-butyl; sec-butyl; tert-butyl; CH₂CF₃; C(═O)-methyl; C(═O)-ethyl; C(═O)—OH; C(═O)—O-methyl; C(═O)—O-ethyl; C(═O)—NH₂; C(═O)—N(methyl)_(2i) C(═O)—N(ethyl)_(2i) C(═O)—NH-methyl; C(═O)—NH-ethyl; C(═O)—N(methyl)(ethyl); OH; O-methyl; O-ethyl; O—(CH₂)₂—O—CH₃; O—(CH₂)₂—OH; OCF₃; O—C(═O)-methyl; O—C(═O)-ethyl; NR^(a)R^(b), wherein R^(a) and R^(b) are selected independently of each other from the group consisting of H, methyl, ethyl, (CH₂)₂—O—CH₃ and (CH₂)₂—OH or R^(a) and R^(b) together with the nitrogen atom linking them form a pyrrolidinyl, piperidinyl, 4-methylpiperazinyl or morpholinyl; NHC(═O)-methyl; NHC(═O)-ethyl; SH; SCF₃; S-methyl; S-ethyl; S(═O)₂OH; S(═O)₂O-methyl; benzyl, phenyl, pyridyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents selected independently of one another from the group consisting of F, Cl, Br, I, CN, methyl, ethyl, CF₃, OH, O-methyl and OCF₃.

In particular the substituents R¹, R², R³ and R⁴ are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; methyl; ethyl; C(═O)-methyl; O-methyl; O—(CH₂)₂—O—CH₃; OCF₃; O—C(═O)-methyl; NH—C(═O)-methyl; N(methyl)₂; morpholinyl; S-methyl; SCF₃; benzyl and phenyl, each unsubstituted.

In a most particularly preferred embodiment of the invention R¹, R², R³ and R⁴ are each selected independently of one another from the group consisting of H, F, Cl, CF₃ and OCF₃.

In a further preferred embodiment of the compounds according to the invention the substituent R⁵ is selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)(R⁰ or H); C(═O)O(R⁰ or H); C(═O)N(R⁰ or H)₂; N(R⁰ or H)₂; N(R⁰ or H)—C(═O)—R⁰; N(R⁰ or H)—C(═O)—N(R⁰ or H)₂; SH; SCF₃; SR⁰; S(═O)₂R⁰; S(═O)₂O(R⁰ or H); S(═O)₂—N(R⁰ or H)₂.

In another preferred embodiment of the compounds according to the invention the substituent R⁵ is selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)(R⁰ or H); C(═O)O(R⁰ or H); C(═O)N(R⁰ or H)₂; OR⁰; —O—(C₁₋₈ alkyl)-OH; O—(C₁₋₈ alkyl)-O—C₁₋₈ alkyl; OCF₃; O—C(═O)—R⁰; N(R⁰ or H)₂; N(R⁰ or H)—C(═O)—R⁰; N(R⁰ or H)—C(═O)—N(R⁰ or H)₂; SH; SCF₃; SR⁰; S(═O)₂R⁰; S(═O)₂O(R⁰ or H); S(═O)₂—N(R⁰ or H)₂.

The substituent R⁵ is preferably selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; C(═O)H; C(═O)—OH; C(═O)—NH₂; C₁₋₈ alkyl, O—C₁₋₈ alkyl, C(═O)C₁₋₈ alkyl, C(═O)O—C₁₋₈ alkyl, O—C(═O)—C₁₋₈ alkyl, C(═O)NH—C₁₋₈ alkyl, C(═O)N(C₁₋₈ alkyl)₂, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, NH—C(═O)C₁₋₈ alkyl, N(C₁₋₈ alkyl)-C(═O)C₁₋₈ alkyl, S—C₁₋₈ alkyl, S(═O)₂C₁₋₈ alkyl, S(═O)₂O—C₁₋₈ alkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O-methyl and OH; OCF₃; SH; SCF₃; S(═O)₂OH; NH₂; C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted; benzyl, phenyl, pyridyl or thienyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, NH₂, CN, C₁₋₈ alkyl, O—C₁₋₈ alkyl, CF₃, OH, OCF₃, C(═O)—OH, SCF₃ and S(═O)₂OH.

The substituent R⁵ is particularly preferably selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; CH₂CF₃; C(═O)—OH; C(═O)—NH₂; SH; SCF₃; S(═O)₂OH; NH₂; OCF₃; C₁₋₈ alkyl, O—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, each saturated, branched or unbranched, unsubstituted or mono-, di- or trisubstituted with one or more substituents selected independently of one another from the group consisting of O-methyl and OH; C(═O)C₁₋₈ alkyl, C(═O)O—C₁₋₈ alkyl, O—C(═O)—C₁₋₈ alkyl, C(═O)NH—C₁₋₈ alkyl, C(═O)N(C₁₋₈ alkyl)₂, NH—C(═O)C₁₋₈ alkyl, N(C₁₋₈ alkyl)-0(═O)C₁₋₈ alkyl, N(C(═O)C₁₋₈ alkyl)₂, S—C₁₋₈ alkyl, S(═O)₂O—C₁₋₈ alkyl, each saturated, branched or unbranched, unsubstituted; C₃₋₁₀ cycloalkyl, saturated, unsubstituted; pyrrolidinyl, piperidinyl, 4-methylpiperazinyl, piperazinyl or morpholinyl, each unsubstituted; benzyl, phenyl or pyridyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents selected independently of one another from the group consisting of F, Cl, Br, I, CN, C₁₋₈ alkyl, O—C₁₋₈ alkyl, CF₃, OH and OCF₃.

The substituent R⁵ is most particularly preferably selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; methyl; ethyl; n-propyl; isopropyl; cyclopropyl; n-butyl; sec-butyl; tert-butyl; CH₂CF₃; C(═O)-methyl; C(═O)-ethyl; C(═O)—OH; C(═O)—O-methyl; C(═O)—O-ethyl; C(═O)—NH₂; C(═O)—N(methyl)_(2i) C(═O)—N(ethyl)₂; C(═O)—NH-methyl; C(═O)—NH-ethyl; C(═O)—N(methyl)(ethyl); O-methyl; O-ethyl; O—(CH₂)₂—O—CH₃; O—(CH₂)₂—OH; OCF₃; O—C(═O)-methyl; O—C(═O)-ethyl; NR^(a)R^(b), wherein R^(a) and R^(b) are selected independently of each other from the group consisting of H, methyl, ethyl, (CH₂)₂—O—CH₃, (CH₂)₂—OH, C(═O)-methyl, C(═O)-ethyl or R^(a) and R^(b) together with the nitrogen atom linking them form a pyrrolidinyl, piperidinyl, 4-methylpiperazinyl or morpholinyl; SH; SCF₃; S-methyl; S-ethyl; S(═O)₂OH; S(═O)₂O-methyl; benzyl, unsubstituted or mono-, di- or trisubstituted with one, two or three substituents selected independently of one another from the group consisting of F, Cl, Br, I, CN, methyl, ethyl, CF₃, OH, O-methyl and OCF₃.

In particular the substituent R⁵ is selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; methyl; ethyl; —CH₂—O-methyl, C(═O)-methyl; O-methyl; O—(CH₂)₂—O—CH₃; OCF₃; O—C(═O)-methyl; NH—C(═O)-methyl; N(methyl)_(2i) morpholinyl; S-methyl; SCF₃; benzyl, unsubstituted.

In a most particularly preferred embodiment of the invention R⁵ is methyl, OMe or —CH₂O-methyl.

In a further preferred embodiment the substituent R⁶ stands for

C₁₋₁₀ alkyl or C₂₋₁₀ heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀ cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃, and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂;

C₃₋₁₀ cycloalkyl or heterocyclyl or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, ═O, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃ and S(═O)₂OH;

-   -   and wherein optionally the alkyl chain or heteroalkyl chain can         be branched or unbranched, saturated or unsaturated,         unsubstituted or mono- or polysubstituted with one or more         substituents selected independently of one another from the         group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O,         C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈         alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀         cycloalkyl and heterocyclyl, wherein the aforementioned alkyl         radicals can each be saturated or unsaturated, branched or         unbranched, unsubstituted or mono- or polysubstituted with one         or more substituents selected independently of one another from         the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃,         and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl         can be saturated or unsaturated, unsubstituted or mono- or         polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈         alkyl and N(C₁₋₈ alkyl)₂;         aryl or heteroaryl or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged         aryl or heteroaryl, each unsubstituted or mono- or         polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH,         CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl,         SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl and thienyl, wherein         benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or         mono- or polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH,         CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃         and S(═O)₂OH;     -   and wherein optionally the alkyl chain or heteroalkyl chain can         be branched or unbranched, saturated or unsaturated,         unsubstituted or mono- or polysubstituted with one or more         substituents selected independently of one another from the         group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O,         C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈         alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀         cycloalkyl and heterocyclyl, wherein the aforementioned alkyl         radicals can each be saturated or unsaturated, branched or         unbranched, unsubstituted or mono- or polysubstituted with one         or more substituents selected independently of one another from         the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃,         and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl         can be saturated or unsaturated, unsubstituted or mono- or         polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈         alkyl and N(C₁₋₈ alkyl)₂.

In a further preferred embodiment the substituent R⁶ stands for the following substructure (T1)

wherein R^(8a) and R^(8b) stand independently of each other for H; F; Cl; Br; I; NO₂; OF₃; CN; OH; OCF₃; NH₂; C₁₋₄ alkyl, O—C₁₋₄ alkyl, NH—C₁₋₄ alkyl, N(C₁₋₄ alkyl)₂, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₄ alkyl, OH and OCF₃; C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₄ alkyl, OH, ═O, O—C₁₋₄ alkyl, OCF₃, NH₂, NH—C₁₋₄ alkyl and N(C₁₋₄ alkyl)₂; m stands for 0, 1, 2, 3 or 4; Y stands for O or NR⁹,

-   -   wherein R⁹ stands for H; C₁₋₄ alkyl, saturated or unsaturated,         branched or unbranched, unsubstituted or mono- or         polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, C₁₋₄ alkyl, OH, O—C₁₋₄ alkyl, OCF₃, NH₂, NH—C₁₋₄ alkyl         and N(C₁₋₄ alkyl)₂; or for C₃₋₁₀ cycloalkyl, saturated or         unsaturated, unsubstituted or mono- or polysubstituted with one         or more substituents selected independently of one another from         the group consisting of F, Cl, Br, I, C₁₋₄ alkyl, OH, O—C₁₋₄         alkyl, OCF₃, NH₂, NH—C₁₋₄ alkyl and N(C₁₋₄ alkyl)₂;         n stands for 0 or 1,     -   with the proviso that n does not stand for 1 if m denotes 0;

-   A stands for C₁₋₈ alkyl, saturated or unsaturated, branched or     unbranched, unsubstituted or mono- or polysubstituted with one or     more substituents selected independently of one another from the     group consisting of F, Cl, Br, I, NO₂, CN, OH, ═O, O—C₁₋₄ alkyl,     OCF₃, C(═O)—OH, CF₃, NH₂, NH(C₁₋₄ alkyl), N(C₁₋₄ alkyl)₂, SH, S—C₁₋₄     alkyl, SCF₃ and S(═O)₂OH; C₃₋₁₀ cycloalkyl or heterocyclyl, each     saturated or unsaturated, unsubstituted or mono- or polysubstituted     with one or more substituents selected independently of one another     from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈     alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈     alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl     and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be     unsubstituted or mono- or polysubstituted with one or more     substituents selected independently of one another from the group     consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈     alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH,     S—C₁₋₈ alkyl, SCF₃ and S(═O)₂OH; aryl or heteroaryl, each     unsubstituted or mono- or polysubstituted with one or more     substituents selected independently of one another from the group     consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈     alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH,     S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl and thienyl,     wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted     or mono- or polysubstituted with one or more substituents selected     independently of one another from the group consisting of F, Cl, Br,     I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, OF₃, NH₂,     NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃ and S(═O)₂OH.

By preference,

R^(8a) and R^(8b) stand independently of each other for H; F; Cl; Br; I; NO₂; CF₃; CH₂CF₃; CN; OH; OCF₃, NH₂; C₁₋₄ alkyl, 0-C₁₋₄ alkyl, 0-C₁₋₄ alkyl-OH, O—C₁₋₄ alkyl-OCH₃, NH—C₁₋₄ alkyl, N(C₁₋₄ alkyl)₂, each saturated or unsaturated, branched or unbranched, unsubstituted; C₃₋₁₀ cycloalkyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₄ alkyl, OH, O—C₁₋₄ alkyl; m stands for 0, 1, 2, 3 or 4; Y stands for O or NR⁹;

-   -   wherein R⁹ stands for H; C₁₋₄ alkyl, saturated or unsaturated,         unsubstituted; or for C₃₋₁₀ cycloalkyl, saturated or         unsaturated, unsubstituted;         n stands for 0 or 1;     -   with the proviso that n does not stand for 1 if m denotes 0;

-   A stands for C₁₋₈ alkyl, saturated or unsaturated, branched or     unbranched, unsubstituted or mono- or polysubstituted with one or     more substituents selected independently of one another from the     group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₄ alkyl, OCF₃,     CF₃, NH₂, NH(C₁₋₄ alkyl), N(C₁₋₄ alkyl)₂, SCF₃; C₃₋₁₀ cycloalkyl or     heterocyclyl, each saturated or unsaturated, unsubstituted or mono-     or polysubstituted with one or more substituents selected     independently of one another from the group consisting of F, Cl, Br,     I, NO₂, CN, OH, O—C₁₋₄ alkyl, OCF₃, C₁₋₄ alkyl, OF₃, NH₂, NH(C₁₋₄     alkyl), N(C₁₋₄ alkyl)₂, SCF₃; aryl or heteroaryl, each unsubstituted     or mono- or polysubstituted with one or more substituents selected     independently of one another from the group consisting of F, Cl, Br,     I, NO₂, CN, OH, O—C₁₋₄ alkyl, OCF₃, C₁₋₄ alkyl, C(═O)—OH, CF₃, NH₂,     NH(C₁₋₄ alkyl), N(C₁₋₄ alkyl)₂, SH, S—C₁₋₄ alkyl, SCF₃, S(═O)₂OH,     benzyl, phenyl and pyridyl, wherein benzyl, phenyl or pyridyl are     each unsubstituted or mono- or polysubstituted with one or more     substituents selected independently of one another from the group     consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₄ alkyl, OCF₃, C₁₋₄     alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₄ alkyl), N(C₁₋₄ alkyl)₂, SH,     S—C₁₋₄ alkyl, SCF₃ and S(═O)₂OH.

Particularly preferably, R^(8a) and R^(8b) stand independently of each other for H; F; Cl; Br; I; NO₂; CF₃; CN; methyl; ethyl; n-propyl; isopropyl; cyclopropyl; n-butyl; sec-butyl; tert-butyl; CH₂CF₃; OH; O-methyl; O-ethyl; O—(CH₂)₂—O—CH₃; O—(CH₂)₂—OH; OCF₃; NH₂; NH-methyl; N(methyl)₂; NH-ethyl; N(ethyl)₂₁ or N(methyl)(ethyl);

m stands for 1, 2 or 3; n stands for 0; and

-   A stands for C₁₋₄ alkyl, saturated or unsaturated, branched or     unbranched, unsubstituted or mono- or polysubstituted with one or     more substituents selected independently of one another from the     group consisting of F, Cl, Br, I, OH, O—C₁₋₄ alkyl, OCF₃ and CF₃;     C₃₋₁₀ cycloalkyl, saturated, unsubstituted; phenyl, naphthyl,     pyridyl, thienyl, each unsubstituted or mono- or di- or     trisubstituted with one, two or three substituents selected     independently of one another from the group consisting of F, Cl, Br,     I, NO₂, CN, OH, O—C₁₋₄ alkyl, OCF₃, C₁₋₄ alkyl, C(═O)—OH, CF₃, NH₂,     NH(C₁₋₄ alkyl), N(C₁₋₄ alkyl)₂, SH, S—C₁₋₄ alkyl, SCF₃, S(═O)₂OH.

Most particularly preferably, R^(8a) and R^(8b) stand independently of each other for H; F; Cl; Br; I; methyl; ethyl; n-propyl; isopropyl; n-butyl; sec-butyl; tert-butyl; OH; O-methyl; O-ethyl; O—(CH₂)₂—O—CH₃; or O—(CH₂)₂—OH;

m stands for 1, 2 or 3; n stands for 0; and

-   A stands for methyl; ethyl; n-propyl; isopropyl; n-butyl; sec-butyl;     tert-butyl; cyclopropyl; cyclobutyl; cyclopentyl; cyclohexyl;     cycloheptyl; adamantyl; bicyclo[2.2.1]heptyl; bicyclo[2.2.2]octyl;     phenyl, pyridyl, thienyl, each unsubstituted or mono-, di- or     trisubstituted with one, two or three substituents selected     independently of one another from the group consisting of F, Cl, Br,     I, NO₂, CN, OH, O—C₁₋₄ alkyl, OCF₃, C₁₋₄ alkyl, C(═O)—OH, CF₃, NH₂,     NH(C₁₋₄ alkyl), N(C₁₋₄ alkyl)₂, SH, S—C₁₋₄ alkyl, SCF₃ and S(═O)₂OH.

In a particularly preferred embodiment

R^(8a) and R^(8b) stand independently of each other for H, m stands for 1, n for 0 and A for phenyl, pyridyl or thienyl, each substituted 0, 1, 2 or 3 times with a substituent selected from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₄ alkyl, OCF₃, C₁₋₄ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₄ alkyl), N(C₁₋₄ alkyl)₂, SH, S—C₁₋₄ alkyl, SCF₃ and S(═O)₂OH.

For n=0 the substructure (T-1) gives rise for R⁶ to the substructure (T1-1):

Compounds according to the invention having the general formula (Ia) are particularly preferred:

In a further preferred embodiment the substituent R⁷ stands for

C₁₋₁₀ alkyl or C₂₋₁₀ heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀ cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃, and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂; C₃₋₁₀ cycloalkyl or heterocyclyl or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, ═O, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl, thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃ and S(═O)₂OH;

-   -   and wherein optionally the alkyl chain or heteroalkyl chain can         be branched or unbranched, saturated or unsaturated,         unsubstituted or mono- or polysubstituted with one or more         substituents selected independently of one another from the         group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O,         C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈         alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀         cycloalkyl and heterocyclyl, wherein the aforementioned alkyl         radicals can each be saturated or unsaturated, branched or         unbranched, unsubstituted or mono- or polysubstituted with one         or more substituents selected independently of one another from         the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃;         and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl         can be saturated or unsaturated, unsubstituted or mono- or         polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈         alkyl and N(C₁₋₈ alkyl)₂;         aryl or heteroaryl or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged         aryl or heteroaryl, each unsubstituted or mono- or         polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH,         CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl,         SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl, thienyl, wherein         benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or         mono- or polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH,         CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃         and S(═O)₂OH;     -   and wherein optionally the alkyl chain or heteroalkyl chain can         be branched or unbranched, saturated or unsaturated,         unsubstituted or mono- or polysubstituted with one or more         substituents selected independently of one another from the         group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O,         C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈         alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀         cycloalkyl and heterocyclyl, wherein the aforementioned alkyl         radicals can each be saturated or unsaturated, branched or         unbranched, unsubstituted or mono- or polysubstituted with one         or more substituents selected independently of one another from         the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃,         and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl         can be saturated or unsaturated, unsubstituted or mono- or         polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈         alkyl and N(C₁₋₈ alkyl)₂.         R⁷ preferably stands for         C₁₋₈ alkyl or C₂₋₈ heteroalkyl, each saturated or unsaturated,         branched or unbranched, unsubstituted or mono- or         polysubstituted with one or more substituents each selected         independently of one another from the group consisting of F, Cl,         Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH,         SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl,         N(C₁₋₈ alkyl)₂, C₃₋₈ cycloalkyl or heterocyclyl, wherein the         aforementioned alkyl radicals can each be saturated or         unsaturated, branched or unbranched, unsubstituted or mono- or         polysubstituted with one or more substituents each selected         independently of one another from the group consisting of F, Cl,         Br, I, O—C₁₋₈ alkyl, OH and OCF₃, and wherein the aforementioned         C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or         unsaturated, unsubstituted or mono- or polysubstituted with one         or more substituents each selected independently of one another         from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O,         O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂;         C₃₋₈ cycloalkyl or heterocyclyl or C₁₋₆ alkyl- or C₂₋₆         heteroalkyl-bridged C₃₋₈ cycloalkyl or heterocyclyl, each         saturated or unsaturated, unsubstituted or mono- or         polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, NO₂, CN, OH, ═O, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl,         C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈         alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl, thienyl, wherein         benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or         mono- or polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH,         CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃         and S(═O)₂OH;     -   and wherein optionally the alkyl chain or heteroalkyl chain can         be branched or unbranched, saturated or unsaturated,         unsubstituted or mono- or polysubstituted with one or more         substituents selected independently of one another from the         group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O,         C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈         alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₈         cycloalkyl and heterocyclyl, wherein the aforementioned alkyl         radicals can each be saturated or unsaturated, branched or         unbranched, unsubstituted or mono- or polysubstituted with one         or more substituents each selected independently of one another         from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and         OCF₃; and wherein the aforementioned C₃₋₁₀ cycloalkyl or         heterocyclyl can be saturated or unsaturated, unsubstituted or         mono- or polysubstituted with one or more substituents each         selected independently of one another from the group consisting         of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂,         NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂;         aryl or heteroaryl or C₁₋₆ alkyl- or C₂₋₆ heteroalkyl-bridged         aryl or heteroaryl, each unsubstituted or mono- or         polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH,         CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl,         SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl, thienyl, wherein         benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or         mono- or polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH,         CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃         and S(═O)₂OH;     -   and wherein optionally the alkyl chain or heteroalkyl chain can         be branched or unbranched, saturated or unsaturated,         unsubstituted or mono- or polysubstituted with one or more         substituents selected independently of one another from the         group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O,         C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈         alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀         cycloalkyl and heterocyclyl, wherein the aforementioned alkyl         radicals can each be saturated or unsaturated, branched or         unbranched, unsubstituted or mono- or polysubstituted with one         or more substituents selected independently of one another from         the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃,         and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl         can be saturated or unsaturated, unsubstituted or mono- or         polysubstituted with one or more substituents selected         independently of one another from the group consisting of F, Cl,         Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈         alkyl and N(C₁₋₈ alkyl)₂.         R⁷ is particularly preferably selected from the group consisting         of methyl, ethyl, n-propyl, isopropyl, n-butyl, 2-butyl,         tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl,         cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, methyl         cyclopropyl, methyl cyclobutyl, methyl cyclopentyl, methyl         cyclohexyl, ethyl cyclopropyl, ethyl cyclobutyl, ethyl         cyclopentyl, ethyl cyclohexyl, each unsubstituted or mono- or         polysubstituted with one or more substituents selected from the         group consisting of F, Cl, Br, I, OCF₃, SCF₃, CF₃ and OC₁₋₈         alkyl; or phenyl, benzyl or phenethyl, each unsubstituted or         mono- or polysubstituted with one or more substituents selected         from the group consisting of F, Cl, Br, I, OCF₃, SCF₃, CF₃, C₁₋₈         alkyl, OC₁₋₈ alkyl and CN.         R⁷ most particularly preferably stands for methyl, ethyl,         isopropyl, tert-butyl or cyclopropyl.

Particularly preferred compounds are those from the group comprising:

-   1 2-(Pentylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide; -   2 3-[[3-[Oxo-(2-thienylmethylamino)methyl]-quinolyl]thio]propanoic     acid methyl ester; -   3 2-(3-Cyclohexylpropylthio)-N-(2-thienylmethyl)-3-quinoline     carboxamide; -   4 2-(3-Phenylpropylthio)-N-(2-thienylmethyl)-3-quinoline     carboxamide; -   5 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienyl-methyl)-3-quinoline     carboxamide; -   6 2-[3-(4-Fluorophenyl)propylthio]-N-(2-thienylmethyl)-3-quinoline     carboxamide; -   7 2-(Ethylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide; -   8     2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienyl-methyl)-6-(trifluoromethyl)-3-quinoline     carboxamide; -   9     2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienylmethyl)-7-(trifluoromethyl)-3-quinoline     carboxamide; -   10     2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienylmethyl)-5-(trifluoromethyl)-3-quinoline     carboxamide; -   11     2-(Pentylthio)-N-(2-thienylmethyl)-6-(trifluoromethyl)-3-quinoline     carboxamide; -   12 2-(Ethylthio)-N-(2-thienylmethyl)-6-(trifluoromethyl)-3-quinoline     carboxamide; -   13     N-(2-Thienylmethyl)-2-[2-[3-(trifluoromethyl)-phenyl]sulfonylethylthio]-3-quinoline     carboxamide; -   14 2-(Ethylthio)-N-(2-thienylmethyl)-7-(trifluoromethyl)-3-quinoline     carboxamide; -   15     2-(Pentylthio)-N-(2-thienylmethyl)-7-(trifluoromethyl)-3-quinoline     carboxamide; -   16     2-[2-(4-Fluorophenyl)sulfonylethylthio]-N-(2-thienylmethyl)-3-quinoline     carboxamide; -   17 2-[2-(p-Tolylsulfonyl)ethylthio]-N-(2-thienylmethyl)-3-quinoline     carboxamide; -   18 2-[2-(p-Tolylthio)ethylthio]-N-(2-thienylmethyl)-3-quinoline     carboxamide; -   19 2-[2-(Phenylsulfonyl)ethylthio]-N-(cyclohexylmethyl)-3-quinoline     carboxamide; -   20 2-[3-(p-Tolyl)propylthio]-N-(2-thienylmethyl)-3-quinoline     carboxamide; -   21 2-[2-(Phenylthio)ethylthio]-N-(2-thienylmethyl)-3-quinoline     carboxamide; -   22 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-cyclohexylethyl)-3-quinoline     carboxamide; -   23 2-[2-(Phenylsulfonyl)ethylthio]-N-(3,3-dimethylbutyl)-3-quinoline     carboxamide; -   24     2-[2-[(4-Fluorophenyl)thio]ethylthio]-N-(2-thienylmethyl)-3-quinoline     carboxamide; -   25     N-(3,3-Dimethylbutyl)-2-(ethylthio)-4-methyl-7-(trifluoromethyl)-3-quinoline     carboxamide; -   26     3-(3-(Thiophen-2-ylmethylcarbamoyl)-6-(trifluoromethyl)quinolin-2-ylthio)propanoic     acid methyl ester; -   27     3-(3-(Thiophen-2-ylmethylcarbamoyl)-7-(trifluoromethyl)quinolin-2-ylthio)propanoic     acid methyl ester; -   28     N-(2,2-Dimethylpropyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   29     N-(Cycloheptylmethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   31     N-[(3,4-Difluorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   32     N-[(2,4-Difluorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   33     2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[(3,4,5-trifluorophenyl)-methyl]-quinoline-3-carboxamide -   34     2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[(2,4,5-trifluorophenyl)-methyl]-quinoline-3-carboxamide -   35     2-Ethylsulfanyl-4-methyl-N-(pyridin-4-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   36     N-[(4-tert-Butylphenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   37     2-Ethylsulfanyl-4-methyl-N-(3-methylbutyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   38     2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[[3-(trifluoromethyl)phenyl]-methyl]-quinoline-3-carboxamide -   39     2-Ethylsulfanyl-4-methyl-N-phenethyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   40     2-Ethylsulfanyl-4-methyl-N-(3-phenylpropyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   41     2-Ethylsulfanyl-4-methyl-N-(pyridin-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   42     2-Ethylsulfanyl-4-methyl-N-(pyridin-3-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   43     2-Ethylsulfanyl-4-methyl-N-(naphthalen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   44     2-Ethylsulfanyl-4-methyl-N-(thiazol-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   45     2-Ethylsulfanyl-4-methyl-N-([1,3,4]oxadiazol-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide

47 N-[(3-Fluorophenyl)-methyl]-2-(isopropylsulfanyl)-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

-   48     2-(Cyclopentylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   49     2-(Butylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   50     N-[(3-Fluorophenyl)-methyl]-4-methyl-2-(pentylsulfanyl)-7-(trifluoromethyl)-quinoline-3-carboxamide

51 N-[(3-Fluorophenyl)-methyl]-4-methyl-2-(1-methyl-propylsulfanyl)-7-(trifluoromethyl)-quinoline-3-carboxamide

-   52     2-(Cyclohexylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

53 N-(2-Cyclopentylethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

54 N-(3-Cyclopentylpropyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

-   55     2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[[4-(trifluoromethyl)-phenyl]-methyl]-quinoline-3-carboxamide

56 N-[(3-tert-Butylphenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

-   57     2-Ethylsulfanyl-4-methyl-N-(4-methylpentyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   58     2-Benzylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   59     2-Ethylsulfanyl-N-[(3-fluoro-2-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   60     2-Ethylsulfanyl-N-[(5-fluoro-2-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   61     N-[(3,4-Dimethylphenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   62     2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[[4-(trifluoromethylsulfanyl)-phenyl]-methyl]-quinoline-3-carboxamide

63 N-(Cyclohexylmethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

-   64     2-Ethylsulfanyl-4-methyl-N-(tetrahydropyran-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   65     2-Ethylsulfanyl-4-methyl-N-propyl-7-(trifluoromethyl)-quinoline-3-carboxamide

66 N-Butyl-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

-   67     2-Ethylsulfanyl-N-(2-methoxyethyl)-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   68     2-Ethylsulfanyl-4-methyl-N-pentyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   69     2-Ethylsulfanyl-4-methyl-N-[(5-methylthiophen-2-yl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide -   70     2-Ethylsulfanyl-4-methyl-N-[(4-methylthiophen-2-yl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide

71 N-[(5-Chlorothiophen-2-yl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

-   72     2-Ethylsulfanyl-4-methyl-N-(2-thiophen-2-yl-ethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide

73 N-(5-Bicyclo[2.2.1]heptanylmethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

74 N-Benzyl-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

-   75     2-Ethylsulfanyl-N-[(2-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   76     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   77     2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

78 N-[(2-Chlorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

79 N-[(3-Chlorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

80 N-[(4-Chlorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

-   81     2-Ethylsulfanyl-4-methyl-N-(o-tolylmethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   82     2-Ethylsulfanyl-4-methyl-N-(m-tolylmethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   83     2-Ethylsulfanyl-4-methyl-N-(p-tolylmethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   84     2-Ethylsulfanyl-N-[(2-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   85     2-Ethylsulfanyl-N-[(3-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   86     2-Ethylsulfanyl-N-[(4-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

87 N-[(3,5-Difluorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

-   88     4-Methyl-2-methylsulfanyl-N-(thiophen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide -   89     2-(tert-Butylsulfanyl)-4-methyl-N-(thiophen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide

90 N-(2,2-Dimethylpropyl)-2-ethylsulfanyl-7-(trifluoromethyl)-quinoline-3-carboxamide

-   91     2-Ethylsulfanyl-4-methyl-N-(thiophen-2-yl-methyl)-quinoline-3-carboxamide -   92     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   93     2-(tert-Butylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   94     2-(tert-Butylsulfanyl)-N-[(4-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   95     7-tert-Butyl-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   96     7-tert-Butyl-2-ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   97     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-methoxy-4-methyl-quinoline-3-carboxamide -   98     2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-7-methoxy-4-methyl-quinoline-3-carboxamide -   99     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4,6-dimethyl-quinoline-3-carboxamide -   100     2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4,6-dimethyl-quinoline-3-carboxamide -   101     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-6-methoxy-4-methyl-quinoline-3-carboxamide -   102     2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-6-methoxy-4-methyl-quinoline-3-carboxamide -   103     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-6-(trifluoromethyl)-quinoline-3-carboxamide -   104     2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-6-(trifluoromethyl)-quinoline-3-carboxamide -   105     2-Ethylsulfanyl-7-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   106     2-Ethylsulfanyl-7-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   107     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4,7-dimethyl-quinoline-3-carboxamide -   108     2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4,7-dimethyl-quinoline-3-carboxamide -   109     2-Ethylsulfanyl-6,7-difluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   110     2-Ethylsulfanyl-N-(furan-2-yl-methyl)-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   111     2-Ethylsulfanyl-4-methyl-N-[(5-methyl-furan-2-yl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide -   113     2-Ethylsulfanyl-N-[(3-hydroxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   114     N-[(3-Fluorophenyl)-methyl]-4-methyl-2-methylsulfanyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   115     N-[(4-Fluorophenyl)-methyl]-4-methyl-2-methylsulfanyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   116     2-Ethylsulfanyl-6-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   117     2-Ethylsulfanyl-6-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   118     2-Ethylsulfanyl-6,7-difluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   119     2-Ethylsulfanyl-N-[(4-hydroxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide -   120     2-Ethylsulfanyl-8-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   121     2-Ethylsulfanyl-8-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   123     2-Ethylsulfanyl-5-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   124     2-Ethylsulfanyl-5-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   125     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-5-methoxy-4-methyl-quinoline-3-carboxamide -   126     2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-5-methoxy-4-methyl-quinoline-3-carboxamide -   127     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-5-hydroxy-4-methyl-quinoline-3-carboxamide -   128     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-6-hydroxy-4-methyl-quinoline-3-carboxamide -   129     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-hydroxy-4-methyl-quinoline-3-carboxamide -   133     7-Dimethylamino-2-ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   134     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-morpholin-4-yl-quinoline-3-carboxamide -   135     2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-7-morpholin-4-yl-quinoline-3-carboxamide -   136     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-8-(trifluoromethyl)-quinoline-3-carboxamide -   137     2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-8-(trifluoromethyl)-quinoline-3-carboxamide -   138     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-8-methoxy-4-methyl-quinoline-3-carboxamide -   139     2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-8-methoxy-4-methyl-quinoline-3-carboxamide -   140     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-8-hydroxy-4-methyl-quinoline-3-carboxamide -   141     7-Dimethylamino-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide -   142     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyloxy)-quinoline-3-carboxamide -   143     4-Ethyl-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide -   144     2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-isopropyl-7-(trifluoromethyl)-quinoline-3-carboxamide     or the physiologically compatible salts thereof.

The substituted 2-mercaptoquinoline-3-carboxamides according to the invention and the corresponding acids, bases, salts and solvates are suitable as pharmaceutical active ingredients in medicaments.

The invention therefore also provides a medicament containing at least one substituted 2-mercaptoquinoline-3-carboxamide according to the invention having the general formula (I), wherein the radicals R¹ to R⁷ have the meaning given above, and optionally one or more pharmaceutically compatible auxiliary substances.

The medicaments according to the invention optionally contain, in addition to at least one compound according to the invention, suitable additives and/or auxiliary substances, including carrier materials, fillers, solvents, diluents, dyes and/or binders, and can be administered as liquid dosage forms in the form of injection solutions, drops or juices, as semi-solid dosage forms in the form of granules, tablets, pellets, patches, capsules, plasters/spray plasters or aerosols. The choice of auxiliary substances, etc., and the amount thereof to use depend on whether the medicament is to be administered by oral, peroral, parenteral, intravenous, intraperitoneal, intradermal, intramuscular, intranasal, buccal, rectal or local means, for example on the skin, mucous membranes or in the eyes. Preparations in the form of tablets, pastilles, capsules, granules, drops, juices and syrups are suitable for oral administration; solutions, suspensions, easily reconstitutable dry preparations and sprays are suitable for parenteral, topical and inhalative administration. Compounds according to the invention in a depot formulation, in dissolved form or in a plaster, optionally with addition of agents promoting skin penetration, are suitable preparations for percutaneous administration. Preparation forms suitable for oral or percutaneous administration can deliver the compounds according to the invention on a delayed release basis. The compounds according to the invention can also be used in parenteral long-term depot forms, such as implants or implanted pumps, for example. Other additional active ingredients known to the person skilled in the art can be added in principle to the medicaments according to the invention.

These medicaments according to the invention are suitable for influencing KCNQ2/3 channels and exert an agonistic or antagonistic, in particular an agonistic, action.

The medicaments according to the invention are preferably suitable for the treatment of disorders or diseases which are at least partly mediated by KCNQ2/3 channels.

The medicaments according to the invention are preferably suitable for the treatment of one or more diseases chosen from the group consisting of pain, preferably pain chosen from the group consisting of acute pain, chronic pain, neuropathic pain, muscular pain and inflammatory pain; epilepsy, urinary incontinence, anxiety states, dependency, mania, bipolar disorders, migraine, cognitive diseases, dystonia-associated dyskinesias and/or urinary incontinence.

The medicaments according to the invention are particularly preferably suitable for the treatment of pain, most particularly preferably chronic pain, neuropathic pain, inflammatory pain and muscular pain.

The medicaments according to the invention are further particularly preferably suitable for the treatment of epilepsy.

The invention also provides the use of at least one substituted 2-mercaptoquinoline-3-carboxamide according to the invention and optionally one or more pharmaceutically compatible auxiliary substances for the preparation of a medicament for the treatment of disorders or diseases which are at least partly mediated by KCNQ2/3 channels.

Preference is given to the use of at least one substituted 2-mercaptoquinoline-3-carboxamide according to the invention and optionally one or more pharmaceutically compatible auxiliary substances for the preparation of a medicament for the treatment of pain, preferably pain chosen from the group consisting of acute pain, chronic pain, neuropathic pain, muscular pain and inflammatory pain; epilepsy, urinary incontinence, anxiety states, dependency, mania, bipolar disorders, migraine, cognitive diseases, dystonia-associated dyskinesias and/or urinary incontinence.

Particularly preferred is the use of at least one substituted 2-mercaptoquinoline-3-carboxamide according to the invention and optionally one or more pharmaceutically compatible auxiliary substances for the preparation of a medicament for the treatment of pain, most particularly preferably chronic pain, neuropathic pain, inflammatory pain and muscular pain.

Also particularly preferred is the use of at least one substituted 2-mercaptoquinoline-3-carboxamide according to the invention and optionally one or more pharmaceutically compatible auxiliary substances for the preparation of a medicament for the treatment of epilepsy.

The invention also provides at least one substituted 2-mercaptoquinoline-3-carboxamide according to the invention and optionally one or more pharmaceutically compatible auxiliary substances for the treatment of disorders or diseases which are at least partly mediated by KCNQ2/3 channels.

The invention also provides at least one substituted 2-mercaptoquinoline-3-carboxamide according to the invention and optionally one or more pharmaceutically compatible auxiliary substances for the treatment of pain, preferably pain chosen from the group consisting of acute pain, chronic pain, neuropathic pain, muscular pain and inflammatory pain; epilepsy, urinary incontinence, anxiety states, dependency, mania, bipolar disorders, migraine, cognitive diseases, dystonia-associated dyskinesias and/or urinary incontinence.

Particularly preferred is at least one substituted 2-mercaptoquinoline-3-carboxamide according to the invention and optionally one or more pharmaceutically compatible auxiliary substances for the treatment of pain, most particularly preferably chronic pain, neuropathic pain, inflammatory pain and muscular pain.

Particularly preferred is also at least one substituted 2-mercaptoquinoline-3-carboxamide according to the invention and optionally one or more pharmaceutically compatible auxiliary substances for the treatment of epilepsy.

The effectiveness against pain can be demonstrated for example in the Bennett or Chung model (Bennett, G. J. and Xie, Y. K., A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man, Pain 1988, 33(1), 87-107; Kim, S. H. and Chung, J. M., An experimental model for peripheral neuropathy produced by segmental spinal nerve ligation in the rat, Pain 1992, 50(3), 355-363). The effectiveness against epilepsy can be demonstrated for example in the DBA/2 mouse model (De Sarro et al., Naunyn-Schmiedeberg's Arch. Pharmacol. 2001, 363, 330-336).

The substituted 2-mercaptoquinoline-3-carboxamides according to the invention preferably have an EC₅₀ value of at most 10 μM or at most 5 μM, more preferably at most 3 μM or at most 2 μM, even more preferably at most 1.5 μM or at most 1 μM, most preferably at most 0.8 μM or at most 0.5 μM and in particular at most 0.4 μM or at most 0.2 μM. Methods for determining the EC₅₀ value are known to the person skilled in the art. The EC₅₀ value is preferably determined by fluorimetry, particularly preferably by the method described in “Pharmacological experiments”.

The invention also provides methods for preparing the substituted 2-mercaptoquinoline-3-carboxamides according to the invention.

The chemicals and reaction components used in the reactions described below are available commercially or can be produced by conventional methods known to the person skilled in the art.

General Reaction Scheme

In steps ax1, ax6, ax9 and ax16 the protective group PG² of the protected ester S-I or S-VI or S-VIII or S-X, which is a tert-butyl or a benzyl group for example, is cleaved by ester cleavage methods known to the person skilled in the art, optionally in the presence of an acid or a base, and S—I, S-VI, S-VIII or S-X are thus converted into the carboxylic acid S-II or S-VII or S-IX or S-XI.

In steps ax2, ax7 and ax10 the carboxylic acid S-II or S-VII or S-IX can be converted into the corresponding amide S-III or S-IV or S-V by methods familiar to the person skilled in the art. For example, SA or S-VII or S-IX can first be reacted with a suitable chlorinating agent such as thionyl chloride to form the acid chloride, which is then reacted with the primary amine R⁶—NH₂, optionally in the presence of a base, to form the amide S-III or S-IV or S-V. Alternatively, S-II or S-VII or S-IX can be reacted with the primary amine R⁶—NH₂ in the presence of a suitable coupling reagent, such as for example HATU or CDI, optionally with addition of a base.

In steps ax3 and ax5 the thiols S-IV and S-VI protected by the protective group PG¹ can be formed starting from the 2-chloroquinolines S-III and S—I by methods familiar to the person skilled in the art, for example by alkylation with the corresponding thiol PG¹-SH in an ipso-substitution to form the thio ether S-IV and S-VI, optionally in the presence of a base.

In steps ax4, ax8 and ax12 the thiol S-IV or S-VI or S-VII which is protected as a thio ether for example can be converted into the thiol S-V or S-VIII or S-IX by cleaving off the protective group PG¹, optionally in the presence of an acid or a base.

In step ax11 the thiol S-IX can be converted into S-VII, which has a thiol function protected by the protective group PG¹, by methods familiar to the person skilled in the art. Here the thiol S-IX can be alkylated for example by the use of an alkyl halide PG¹-Hal, optionally in the presence of a base.

In step ax13 the thiol S-VIII can be converted into the corresponding thio ether S-X by methods familiar to the person skilled in the art. Here the thiol S-VIII can be alkylated for example by the use of the alkyl halide R⁷-Hal, optionally in the presence of a base.

In step ax14 the 2-chloroquinoline S-I can first be converted into the corresponding thio ether by methods known to the person skilled in the art, such as for example by substitution with a thiol, for example 3-mercaptopropanoic acid ethyl ester, and then cleaved, optionally in the presence of an acid or a base, to form the thiol S-VIII.

In step ax15 the thio ether S-X can be formed starting from the 2-chloroquinoline S-I by methods familiar to the person skilled in the art, e.g. by alkylation with the corresponding thiol R⁷—SH in an ipso-substitution, optionally in the presence of a base.

In step aL1 the thiol S-V can be converted into the corresponding thio ether S-XII by methods familiar to the person skilled in the art. Here the thiol S-V can be alkylated for example by the use of the alkyl halide R⁷-Hal, optionally in the presence of a base.

In step bL1 the carboxylic acid S-XI can be converted into the corresponding amide S-XII by methods familiar to the person skilled in the art. For example, S-XI can first be reacted with a suitable chlorinating agent such as thionyl chloride to form the acid chloride, which is then reacted with the primary amine R⁶—NH₂, optionally in the presence of a base, to form the amide S-XII. Alternatively, S-XI can be reacted with the primary amine R⁶—NH₂ in the presence of a suitable coupling reagent, such as for example HATU or CDI, optionally with addition of a base.

In step cL1 the thio ether S-XII can be formed starting from 2-chloroquinoline S-III by methods familiar to the person skilled in the art, e.g. by alkylation with the corresponding thiol R⁷—SH in an ipso-substitution, optionally in the presence of a base.

The methods familiar to the person skilled in the art for performing reaction steps ax1 to ax16 and aL1, bL1 and cL1 can be found in the standard works on organic chemistry, such as for example J. March, Advanced Organic Chemistry, Wiley & Sons, 6th edition, 2007; F. A. Carey, R. J. Sundberg, Advanced Organic Chemistry, Parts A and B, Springer, 5th edition, 2007); various authors, Compendium of Organic Synthetic Methods, Wiley & Sons. In addition, further methods and references to the literature can be obtained from the standard databases such as the Reaxys® database from Elsevier, Amsterdam, NL or the SciFinder® database of the American Chemical Society, Washington, US.

Description of the Syntheses Abbreviations

-   AcOH acetic acid -   aq. aqueous -   brine saturated aqueous NaCl solution -   BuLi butyl lithium -   d days -   DCM dichloromethane -   DIPEA N,N-diisopropylethylamine -   EE ethyl acetate -   EtOH ethanol -   sat. saturated -   h hour(s) -   HATU O-(7-azabenzotriazol-1-yl)-N,N,N′,N′-tetramethyluronium     hexafluorophosphate -   sol. solution -   m/z mass-to-charge ratio -   M molar -   MeCN acetonitrile -   MeOH methanol -   min minutes -   MS mass spectrometry -   N/A not available -   NEt₃ triethylamine -   RG retigabine -   RT room temperature 23±7° C. -   SC column chromatography on silica gel -   THF tetrahydrofuran -   vv ratio by volume

All starting materials not explicitly described were either available commercially (suppliers can be found for example in the Symyx® Available Chemicals Database from MDL, San Ramon, US), or their synthesis is already accurately described in the specialist literature (experimental procedures can be found for example in the Reaxys® database from Elsevier, Amsterdam, NL), or they can be prepared by the methods known to the person skilled in the art.

Silica gel 60 (0.040-0.063 mm) was used as the stationary phase for column chromatography (SC).

The analytical characterisation of all intermediates and example compounds was performed by means of ¹H-NMR spectroscopy. Analyses by mass spectrometry (MS, m/z stated for [M+H]⁺) were also performed for all example compounds and selected intermediates.

Synthesis of Intermediates Synthesis of Intermediate VVV01: 2-Chloro-N-(thiophen-2-ylmethyl)quinoline-3-carboxamide

A solution of 2.1 g (10.0 mmol) 2-chloroquinoline-3-carboxylic acid in thionyl chloride (60 ml) was heated for 2 h at 85° C. Then excess thionyl chloride was removed under vacuum. The residue was taken up with DCM (60 ml) and the solution was cooled to 0° C. and then mixed with 4.0 ml (30.0 mmol) NEt₃ and 1.03 ml (10.0 mmol) thiophene-2-methylamine. After stirring for 90 min at RT it was diluted with EE and washed with a saturated aqueous NH₄Cl solution. The aqueous phase was extracted with EE. The combined organic phases were washed with brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 4:1) with the residue yielded 1.44 g (4.8 mmol, 48%) 2-chloro-N-(thiophen-2-ylmethyl)quinoline-3-carboxamide.

Synthesis of Intermediate VVV02: 2-Mercapto-N-(thiophen-2-ylmethyl)quinoline-3-carboxamide

600 mg (26.1 mmol) sodium were added slowly to MeOH (500 ml). Then a solution of 1.16 g (3.0 mmol) 3-[[3-oxo-[2-thienylmethylamino)methyl]-2-quinolyl]-thio]propanoic acid methyl ester (Example 2) in MeOH (60 ml) was added at RT. Then the reaction solution was heated for 1 h at 70° C. After cooling to RT the mixture was concentrated to small volume under vacuum. The residue was taken up with water and the solution was washed with EE. Then it was acidified with concentrated hydrochloric acid to pH 3. The deposit formed was filtered off and dried. 805 mg (2.7 mmol, 90%) 2-mercapto-N-(thiophen-2-ylmethyl)quinoline-3-carboxamide were obtained.

Synthesis of Intermediate VVV03: 2-Chloro-6-(trifluoromethyl)quinoline-3-carboxylic acid

A solution of 1.54 ml (11.0 mmol) diisopropylamine in THF (38 ml) was cooled to 0° C. 6.9 ml (1.6 M in hexane, 11.0 mmol) n-BuLi were added dropwise at this temperature and then the mixture was stirred for 30 min at −78° C. Then a solution of 2.31 g (10.0 mmol) 2-chloro-6-(trifluoromethyl)quinoline in THF (12 ml) was added dropwise at −78° C. and the mixture was stirred for a further 30 min at −78° C. Then the reaction solution was poured onto finely dispersed dry ice. After heating to RT the mixture was concentrated to small volume under vacuum and the residue was taken up with water. It was made alkaline with a 1N aqueous NaOH solution and then washed with ether. Then it was acidified with a 10% aqueous hydrochloric acid and extracted with EE. The organic phase was washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. 198 mg (0.7 mmol, 72%) 2-chloro-6-(trifluoromethyl)quinoline-3-carboxylic acid were obtained as residue.

Synthesis of Intermediate VVV04: 2-(2-(Phenylsulfonyl)ethylthio)-6-(trifluoromethyl)quinoline-3-carboxylic acid

206 mg (1.5 mmol) K₂CO₃ and 303 mg (1.5 mmol) 2-(phenylsulfonyl)ethanethiol were added to a solution of 827 mg (1.0 mmol) 2-chloro-6-(trifluoromethyl)quinoline-3-carboxylic acid (precursor VVV03) in acetone (3 ml) and the mixture was heated for 5 h at 70° C. Then it was filtered and the filtrate was concentrated to small volume under vacuum. The residue was dissolved in water and acidified with a 1N hydrochloric acid. It was then extracted with EE and the organic phase was dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Crystallisation (DCM/hexane) of the residue yielded 316 mg (0.7 mmol, 72%) 2-(2-(phenylsulfonyl)ethylthio)-6-(trifluoromethyl)quinoline-3-carboxylic acid.

Synthesis of Intermediate VVV05: 2-Hydroxy-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxylic acid ethyl ester

235 mg (60% in mineral oil, 5.89 mmol) sodium hydride were added to a solution of 1.7 g (5.36 mmol) 3-(2-acetyl-5-(trifluoromethyl)phenylamino)-3-oxopropanoic acid ethyl ester in EtOH (16 ml) and the mixture was refluxed for 3 h and stirred for a further 16 h at RT. Then 1.34 ml (6.70 mmol) AcOH were added and the mixture was diluted with EE (30 ml) and brine (10 ml). The phases were separated and the organic phase was dried over MgSO₄, filtered and concentrated to small volume under vacuum. Crystallisation (EE) of the residue yielded 920 mg (3.07 mmol, 57%) 2-hydroxy-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester.

Synthesis of Intermediate VVV06: 2-Chloro-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester

4.3 g (14.4 mmol) 2-hydroxy-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester (precursor VVV05) were heated together with 13.3 ml (144.1 mmol) POCl₃ for 2 h at 100° C. After cooling to RT the mixture was concentrated to small volume under vacuum. 4.5 g (14.2 mmol, 98%) 2-chloro-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester were obtained as residue.

Synthesis of Intermediate VVV07: 2-(3-Ethoxy-3-oxopropylthio)-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester

336 mg (3.0 mmol) potassium tert-butylate were added to a solution of 360 mg (3.0 mmol) 3-mercaptopropionic acid methyl ester in DMF (8 ml) at 0° C. and the mixture was stirred for 30 min at 0° C. Then 953 mg (3.0 mmol) 2-chloro-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester were added and the reaction solution was heated slowly to 50° C. and stirred for 16 h at this temperature. After cooling to RT the mixture was diluted with water and extracted with EE. The organic phase was dried over MgSO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 9:1) of the residue yielded 625 mg (1.5 mmol, 50%) 2-(3-ethoxy-3-oxopropylthio)-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester.

Synthesis of Intermediate VVV08: 2-(Ethylthio)-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid

400 mg (17.4 mmol) sodium were added slowly to MeOH (50 ml) and the solution was stirred for 5 min at RT. Then a solution of 800 mg (2.0 mmol) 2-(3-ethoxy-3-oxopropylthio)-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester (precursor VVV07) in MeOH (10 ml) was added at RT. The reaction solution was then heated for 30 min at 70° C. After cooling to RT 488 μl (6.0 mmol) 1-iodethane were added and the mixture was stirred for 2 h at RT. Then the mixture was concentrated to small volume under vacuum and the residue was taken up with EE. It was washed with water and the aqueous phase was extracted with EE. The combined organic phases were washed with brine, dried over MgSO₄, filtered and concentrated to small volume under vacuum. 391 mg (1.2 mmol, 62%) 2-(ethylthio)-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid were obtained as the residue, which was reacted further with no additional purification.

Synthesis of Intermediate VVV17: 2-Chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide a) Synthesis of 2-chloro-4-methyl-7-(trifluoromethyl)quinoline-3-carbonyl chloride

50 g (55.3 mmol) 2-hydroxy-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxylic acid ethyl ester (VVV05) were heated together with 51 ml (553.1 mmol) POCl₃ for 2 h at 100° C. Then toluene was added (10 ml) and the mixture was stirred for 10 min at 60° C. and then concentrated to small volume under vacuum. The residue was taken up with water and extracted with EE. The organic phase was washed with a 1M aqueous NaHCO₃ solution, water and brine, dried over MgSO₄, filtered and concentrated to small volume under vacuum. 12.6 g (40.9 mmol, 74%) 2-chloro-4-methyl-7-(trifluoromethyl)quinoline-3-carbonyl chloride were obtained as the residue, which was reacted further with no additional purification.

b) Synthesis of 2-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

A solution of 2.9 g (23.4 mmol) 3-fluorobenzylamine was added dropwise at RT to a solution of 6.0 g (19.5 mmol) 2-chloro-4-methyl-7-(trifluoromethyl)quinoline-3-carbonyl chloride in dioxane (35 ml). The mixture was then stirred for 60 min at RT and then quenched with water. The reaction solution was extracted with EE and the organic phase was washed with a 1M aqueous NH₄Cl solution and brine, dried over MgSO₄, filtered and concentrated to small volume under vacuum. Crystallisation of the residue (EE) yielded 6.4 g (16.1 mmol, 83%) 2-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide.

Synthesis of Intermediate VVV22: 7-tert-Butyl-2-ethylsulfanyl-4-methyl-quinoline-3-carboxylic acid a) Synthesis of 3-(2-acetyl-5-tert-butylphenylamino)-3-oxopropanoic acid ethyl ester

160 μl (1.15 mol) NEt₃ were added to a solution of 200 mg (1.0 mmol) 1-(2-amino-4-tert-butylphenyl)ethanone in DCM (20 ml) and the mixture was cooled to 0° C. 170 μl (1.4 mmol) 3-chloro-3-oxopropanoic acid ethyl ester were added at this temperature and the mixture was then stirred for 2 h at RT. Then it was diluted with water and extracted with DCM. The organic phase was washed with brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 19:1) of the residue yielded 190 mg (0.62 mmol, 60%) 3-(2-acetyl-5-tert-butyl-phenylamino)-3-oxopropanoic acid ethyl ester.

b) Synthesis of 7-tert-butyl-2-hydroxy-4-methyl-quinoline-3-carboxylic acid ethyl ester

30 mg (0.68 mmol, 60% in mineral oil) sodium hydride were added to a solution of 190 mg (0.62 mmol) 3-(2-acetyl-5-tert-butyl-phenylamino)-3-oxopropanoic acid ethyl ester in EtOH (2 ml) and the mixture was heated for 2 h at 80° C. Then it was diluted with water and acidified with 5N AcOH. It was then extracted with EE. The organic phase was washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. 150 mg (0.52 mmol, 84%) 7-tert-butyl-2-hydroxy-4-methyl-quinoline-3-carboxylic acid ethyl ester were obtained as the residue, which was reacted further with no additional purification.

c) Synthesis of 7-tert-butyl-2-chloro-4-methyl-quinoline-3-carboxylic acid ethyl ester

A mixture of 150 mg (0.52 mmol) 7-tert-butyl-2-hydroxy-4-methyl-quinoline-3-carboxylic acid ethyl ester and POCl₃ (1 ml) was heated for 2 h at 150° C. Then the reaction solution was poured into iced water (15 ml) and made alkaline with a saturated aqueous NaHCO₃ solution. It was then extracted with EE and the organic phase was washed with brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. 140 mg (0.46 mmol, 88%) 7-tert-butyl-2-chloro-4-methyl-quinoline-3-carboxylic acid ethyl ester were obtained as the residue, which was reacted further with no additional purification.

d) Synthesis of 7-tert-butyl-2-ethylsulfanyl-4-methyl-quinoline-3-carboxylic acid ethyl ester

190 mg (1.38 mmol) K₂CO₃ and 100 μl (1.38 mmol) ethanethiol were added to a solution of 140 mg (0.46 mmol) 7-tert-butyl-2-chloro-4-methyl-quinoline-3-carboxylic acid ethyl ester in DMF (3 ml) and the mixture was stirred for 16 h at 60° C. Then it was diluted with water and extracted with EE. The organic phase was washed with brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 19:1) of the residue yielded 100 mg (0.30 mmol, 65%) 7-tert-butyl-2-ethylsulfanyl-4-methyl-quinoline-3-carboxylic acid ethyl ester.

e) Synthesis of 7-tert-butyl-2-ethylsulfanyl-4-methyl-quinoline-3-carboxylic acid

A solution of 600 mg (14.36 mmol) lithium hydroxide monohydrate in water (30 ml) was added to a solution of 1.7 g (5.1 mmol) 7-tert-butyl-2-ethylsulfanyl-4-methyl-quinoline-3-carboxylic acid ethyl ester in a THF/methanol blend (2:1 vv, 30 ml) and then the reaction solution was stirred for 16 h at 60° C. Then the mixture was concentrated to small volume under vacuum and the residue was taken up with water and washed with EE. The aqueous phase was adjusted to pH 2 with 1M hydrochloric acid and then extracted with EE. The organic phase was washed with brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. 420 mg (1.38 mmol, 27%) 7-tert-butyl-2-ethylsulfanyl-4-methyl-quinoline-3-carboxylic acid were obtained as the residue, which was reacted further with no additional purification.

Synthesis of Intermediate VVV30: 2-Ethylsulfanyl-6,7-difluoro-4-methyl-quinoline-3-carboxylic acid a) Synthesis of 6,7-difluoro-2-hydroxy-4-methyl-quinoline-3-carboxylic acid ethyl ester

6,7-Difluoro-2-hydroxy-4-methyl-quinoline-3-carboxylic acid ethyl ester was prepared from 1-(2-amino-4,5-difluorophenyl)ethanone by the method described for precursor VVV22 sections a) and b).

b) Synthesis of 2-ethylsulfanyl-6,7-difluoro-4-methyl-quinoline-3-carboxylic acid ethyl ester

3.4 g (8.2 mmol) Lawesson's reagent were added at RT to a solution of 550 mg (2.1 mmol) 6,7-difluoro-2-hydroxy-4-methyl-quinoline-3-carboxylic acid ethyl ester in a pyridine/toluene blend (1:10 vv, 6 ml) and then the mixture was heated for 3 h at 80° C. Then it was quenched with a saturated aqueous NaHCO₃ solution (20 ml) and extracted with EE (3×60 ml). The combined organic phases were washed with water, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. The residue (450 mg) was dissolved in DMF (6 ml) and mixed with 660 mg (4.8 mmol) K₂CO₃ and 740 mg (4.8 mmol) iodoethane. The reaction solution was then heated for 30 min at 50° C. It was then diluted with water (60 ml) and extracted with EE (3×80 ml). The combined organic phases were washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 19:1) of the residue yielded 300 mg (0.96 mmol, 47%) 2-ethylsulfanyl-6,7-difluoro-4-methyl-quinoline-3-carboxylic acid ethyl ester.

c) Synthesis of 2-ethylsulfanyl-6,7-difluoro-4-methyl-quinoline-3-carboxylic acid

220 mg (0.78 mmol, 60%) 2-ethylsulfanyl-6,7-difluoro-4-methyl-quinoline-3-carboxylic acid were prepared from 400 mg (1.3 mmol) 2-ethylsulfanyl-6,7-difluoro-4-methyl-quinoline-3-carboxylic acid by the method described for precursor VVV22 section e).

Synthesis of Intermediate VVV39: 7-Dimethylamino-2-ethylsulfanyl-4-methyl-quinoline-3-carboxylic acid ethyl ester a) Synthesis of 2-ethylsulfanyl-7-fluoro-4-methyl-quinoline-3-carboxylic acid ethyl ester

2-Ethylsulfanyl-7-fluoro-4-methyl-quinoline-3-carboxylic acid ethyl ester was prepared from 1-(2-amino-4-fluorophenyl)ethanone by the method described for precursor VVV30 sections a) and b).

b) Synthesis of 7-dimethylamino-2-ethylsulfanyl-4-methyl-quinoline-3-carboxylic acid ethyl ester

2.8 g (20.5 mmol) K₂CO₃ and a 40% aq. dimethylamine solution (20.5 ml) were added to a solution of 2.0 g (6.8 mmol) 2-ethylsulfanyl-7-fluoro-4-methyl-quinoline-3-carboxylic acid ethyl ester in EtOH (20 ml) and the mixture was heated for 16 h at 90° C. in a closed vessel. Then the reaction solution was concentrated to small volume under vacuum and the residue was taken up with water. It was then extracted with EE. The organic phase was washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 25:1) of the residue yielded 810 mg (2.55 mmol, 38%) 7-dimethylamino-2-ethylsulfanyl-4-methyl-quinoline-3-carboxylic acid ethyl ester.

Synthesis of Intermediate VVV41: 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-hydroxy-7-(trifluoromethyl)-quinoline-3-carboxamide a) Synthesis of N-(1-ethylthio-2-(1-oxybutyl)-hexan-3-onylidene)-3-(trifluoromethyl)aniline

A solution of 7.2 g (45.0 mmol) diethyl malonate in DMF (10 ml) was added to a solution of 2.0 g (41.2 mmol) sodium hydride in DMF (120 ml) and the mixture was then stirred at RT for 30 min. Then a solution of 10.0 g (37.5 mmol) N-(1-chloro-1-ethylthio-methylene)-3-(trifluoromethyl) aniline in DMF (10 ml) was added and the reaction solution was heated for 30 min at 100° C. Then it was diluted with water and extracted with ether. The organic phase was washed with water, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. 4.5 g (11.5 mmol, 31%) N-(1-ethylthio-2-(1-oxybutyl)-hexan-3-onylidene)-3-(trifluoromethyl)aniline were obtained as the residue, which was reacted further with no additional purification.

b) Synthesis of 2-(ethylthio)-4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester

4.0 g (10.2 mmol) N-(1-ethylthio-2-(1-oxybutyl)-hexan-3-onylidene)-3-(trifluoromethyl)aniline were heated under vacuum for 1 h at 180° C. After cooling to RT and column chromatography (hexane/EE 249:1) of the residue, 1.0 g (2.9 mmol, 28%) 2-(ethylthio)-4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester were obtained.

c) Synthesis of 2-(ethylthio)-N-(3-fluorobenzyl)-4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxamide

5.8 ml (11.6 mmol, 2M in toluene)trimethyl aluminium and 1.5 g (11.6 mmol) 3-fluorobenzylamine were added in succession to a solution of 1.0 g (2.9 mmol) 2-(ethylthio)-4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxylic acid ethyl ester in toluene (18 ml) and the mixture was then heated for 2 h at 80° C. Then it was diluted with water and extracted with EE. The organic phase was washed with 1M hydrochloric acid, water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 17:3) of the residue yielded 0.9 g (2.1 mmol, 73%) 2-(ethylthio)-N-(3-fluorobenzyl)-4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxamide.

Synthesis of Further Intermediates

The synthesis of further intermediates took place by the methods already described. Table 1 shows which compound was prepared by which method. The starting materials and reagents used in each case are apparent to the person skilled in the art.

TABLE 1 Preparation analogous to Intermediate Chemical name intermediate VVV09 2-Chloro-N-(cyclohexylmethyl)quinoline-3-carboxamide VVV01 VVV10 2-Chloro-N-(2-cyclohexylethyl)quinoline-3-carboxamide VVV01 VVV11 2-Chloro-N-(3,3-dimethylbutyl)quinoline-3-carboxamide VVV01 VVV12 2-Chloro-7-(trifluoromethyl)quinoline-3-carboxylic acid VVV03 VVV13 2-Chloro-N-(thiophen-2-ylmethyl)-7- VVV01 (trifluoromethyl)quinoline-3-carboxamide VVV14 2-(3-Methoxy-3-oxopropylthio)-6- VVV04 (trifluoromethyl)quinoline-3-carboxylic acid VVV15 2-Chloro-5-(trifluoromethyl)quinoline-3-carboxylic acid VVV03 VVV16 2-Chloro-N-(thiophen-2-ylmethyl)-5- VVV01 (trifluoromethyl)quinoline-3-carboxamide VVV18 4-Methyl-2-methylsulfanyl-7-(trifluoromethyl)- VVV08 quinoline-3-carboxylic acid VVV19 2-(tert-Butylsulfanyl)-4-methyl-7-(trifluoromethyl)- VVV22 quinoline-3-carboxylic acid VVV21 2-Ethylsulfanyl-4-methyl-quinoline-3-carboxylic acid VVV22 VVV23 2-Ethylsulfanyl-7-methoxy-4-methyl-quinoline-3- VVV22 carboxylic acid VVV24 2-Ethylsulfanyl-4,6-dimethyl-quinoline-3-carboxylic acid VVV22 VVV25 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyloxy)- VVV22 quinoline-3-carboxylic acid ethyl ester without section e) VVV26 4-Ethyl-2-ethylsulfanyl-7-(trifluoromethyl)-quinoline- VVV08 3-carboxylic acid VVV27 2-Ethylsulfanyl-4-isopropyl-7-(trifluoromethyl)- VVV08 quinoline-3-carboxylic acid VVV28 2-Ethylsulfanyl-8-methoxy-4-methyl-quinoline-3- VVV22 carboxylic acid ethyl ester without section e) VVV29 2-Ethylsulfanyl-4-methyl-8-(trifluoromethyl)- VVV22 quinoline-3-carboxylic acid ethyl ester without section e) VVV31 2-Ethylsulfanyl-5-fluoro-4-methyl-quinoline-3- VVV30 carboxylic acid VVV32 2-Ethylsulfanyl-8-fluoro-4-methyl-quinoline-3- VVV30 carboxylic acid VVV33 2-Ethylsulfanyl-7-fluoro-4-methyl-quinoline-3- VVV22 carboxylic acid VVV34 2-Ethylsulfanyl-6-fluoro-4-methyl-quinoline-3- VVV22 carboxylic acid VVV35 2-Ethylsulfanyl-4,7-dimethyl-quinoline-3-carboxylic VVV22 acid VVV36 2-Ethylsulfanyl-5-methoxy-4-methyl-quinoline-3- VVV22 carboxylic acid VVV37 2-Ethylsulfanyl-6-methoxy-4-methyl-quinoline-3- VVV22 carboxylic acid VVV38 2-Ethylsulfanyl-4-methyl-6-(trifluoromethyl)- VVV22 quinoline-3-carboxylic acid VVV40 2-Ethylsulfanyl-4-methyl-7-morpholin-4-yl- VVV39 + quinoline-3-carboxylic acid VVV22 section e)

Synthesis of the Example Compounds Synthesis of Example Compound 1: 2-(Pentylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide

A solution of 300 mg (1.0 mmol) 2-mercapto-N-(thiophen-2-ylmethyl)quinoline-3-carboxamide (precursor VVV02) in DMF (2.3 ml) was mixed with 151 mg (1.1 mmol) K₂CO₃ at room temperature and stirred for 30 min. Then 131 μl (1.0 mmol) 1-iodopentane were added and the mixture was stirred for a further 3 days at RT. Then the mixture was concentrated to small volume under vacuum and the residue was taken up with EE and washed with water. The aqueous phase was extracted with EE and the combined organic phases were dried over MgSO₄, filtered and concentrated to small volume under vacuum. Crystallisation of the residue from EE yielded 146 mg (0.4 mmol, 39%) 2-(pentylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide. MS: m/z 371.1 [M+H]⁺.

Synthesis of Example Compound 2: 3-{[3-[Oxo-(2-thienylmethylamino)methyl]-2-quinolyl]thio}propanoic acid methyl ester

A solution of 361 mg (3.0 mmol) 3-mercaptopropionic acid methyl ester in DMF (18 ml) was cooled to 0° C. and mixed with 336.6 mg (3.0 mmol) potassium tert-butylate and stirred for 10 min. Then 908 mg (3.0 mmol) 2-chloro-N-(thiophen-2-ylmethyl)quinoline-3-carboxamide (precursor VVV01) were added and the reaction solution was then heated slowly to 50° C. and stirred for 16 h at this temperature. It was then diluted with EE and washed with a saturated aqueous NH₄Cl solution. The aqueous phase was extracted with EE. The combined organic phases were washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 4:1) with the residue yielded 614 mg (1.6 mmol, 53%) 3-[[3-[oxo-(2-thienylmethylamino)methyl]-2-quinolyl]thio]propanoic acid methyl ester. MS: m/z 387.1 [M+H]⁺.

Synthesis of Example Compound 5: 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienyl-methyl)-3-quinoline carboxamide

112 mg (1.0 mmol) potassium tert-butylate were added to a solution of 202 mg (1.0 mmol) 2-(phenylsulfonyl)ethanethiol in DMF (6 ml) at 0° C. and the mixture was stirred for 10 min at 0° C. Then 303 mg (1.0 mmol) 2-chloro-N-(thiophen-2-ylmethyl)quinoline-3-carboxamide (precursor VVV01) were added at 0° C. and the reaction solution was heated slowly to 50° C. and stirred for 16 h at this temperature. After cooling to RT it was diluted with EE and washed with a saturated aqueous NH₄Cl solution. The aqueous phase was extracted with EE. The combined organic phases were washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 4:1) with the residue yielded 326 mg (0.7 mmol, 70%) 2-[2-(phenylsulfonyl)ethylthio]-N-(2-thienyl-methyl)-3-quinoline carboxamide. MS: m/z 469.1 [M+H]⁺.

Synthesis of Example Compound 7: 2-(Ethylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide

A solution of 303 mg (1.0 mmol) 2-chloro-N-(thiophen-2-ylmethyl)quinoline-3-carboxamide (precursor VVV01) in ethanol (10 ml) was mixed with 92 mg (1.1 mmol) sodium thioethanolate and refluxed for 90 min. Then it was poured onto water and extracted repeatedly with EE. The combined organic phases were dried over MgSO₄, filtered and concentrated to small volume under vacuum. Crystallisation (EE/hexane) of the residue yielded 103 mg (0.3 mmol, 31%) 2-(ethylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide. MS: m/z 329.1 [M+H]⁺.

Synthesis of Example Compound 8: 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienyl-methyl)-6-(trifluoromethyl)-3-quinoline carboxamide

A solution of 441 mg (1.0 mmol) 2-(2-(phenylsulfonyl)ethylthio)-6-(trifluoromethyl)-quinoline-3-carboxylic acid (precursor VVVO4) in DMF (5 ml) was mixed with 456 mg (1.2 mmol) HATU and 680 μl (4.0 mmol) DIPEA and stirred for 15 h at RT. Then it was diluted with EE and washed with a saturated aqueous NH₄Cl solution, a saturated aqueous NaHCO₃ solution and brine. The organic phase was dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 7:3) of the residue yielded 107 mg (0.2 mmol, 20%) 2-[2-(phenylsulfonyl)ethylthio]-N-(2-thienylmethyl)-6-(trifluoromethyl)-3-quinoline carboxamide. MS: m/z 537.1 [M+H]⁺.

Synthesis of Example Compound 11: 2-(Pentylthio)-N-(2-thienylmethyl)-6-(trifluoromethyl)-3-quinoline carboxamide

198 mg (8.6 mmol) sodium were added slowly to MeOH (86 ml) and the solution was stirred for 5 min at RT. Then a solution of 455 mg (1.0 mmol) 3-(3-(thiophen-2-ylmethylcarbamoyl)-6-(trifluoromethyl)quinolin-2-ylthio)propanoic acid methyl ester (Example 26) in MeOH (10 ml) was added at RT. The reaction solution was then heated for 30 min at 70° C. Then 396 μl (3.0 mmol) 1-iodopentane were added at RT and the mixture was stirred for 1 h at RT. Then the mixture was concentrated to small volume under vacuum and the residue was taken up with EE. It was washed with water and brine and the organic phase was dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. 167 mg (0.4 mmol, 38%) 2-(pentylthio)-N-(2-thienylmethyl)-6-(trifluoromethyl)-3-quinoline carboxamide were obtained as residue. MS: m/z 439.1 [M+H]⁺.

Synthesis of Example Compound 13: N-(2-Thienylmethyl)-2-[2-[3-(trifluoromethyl)-phenyl]sulfonylethylthio]-3-quinoline carboxamide

151 mg (1.1 mmol) K₂CO₃ and 300 mg (1.1 mmol) 1-(2-chloroethylsulfonyl)-3-(trifluoromethyl)benzene were added to a solution of 300 mg (1.0 mmol) 2-mercapto-N-(thiophen-2-ylmethyl)quinoline-3-carboxamide (precursor VVV02) in acetone (10 ml) at RT and the mixture was heated for 3 h at 70° C. Then it was filtered and the filtrate was concentrated to small volume under vacuum. The residue was taken up with EE and washed with water and brine, dried over MgSO₄, filtered and concentrated to small volume under vacuum. Column chromatography (DCM/EE 20:1) of the residue yielded 163 mg (0.3 mmol, 30%) N-(2-thienylmethyl)-2-[2-[3-(trifluoromethyl)-phenyl]sulfonylethylthio]-3-quinoline carboxamide. MS: m/z 537.1 [M+H]⁺.

Synthesis of Example Compound 30: 2-Ethylsulfanyl-4-methyl-N-(thiophen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide

134 μl (1.3 mmol) thiophenemethanamine, 438 mg (1.1 mmol) HATU and 420 μl (3.0 mmol) NEt₃ were added in succession to a solution of 330 mg (1.05 mmol) 2-(ethylthio)-4-methyl-7-(trifluoromethyl)quinoline-3-carboxylic acid (VVV08) in THF (8 ml) and the mixture was then heated for 24 h at 50° C. Then it was diluted with EE and washed with a 4M aqueous NH₄Cl solution, a 1M aqueous Na₂CO₃ solution and brine. The organic phase was dried over MgSO₄ and then filtered through a silica layer. Column chromatography (hexane/EE 7:3) of the residue yielded 277 mg (0.67 mmol, 65%) 2-ethylsulfanyl-4-methyl-N-(thiophen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide. MS: m/z 411.1 [M+H]⁺.

Synthesis of Example Compound 46: N-[(3-Fluorophenyl)-methyl]-4-methyl-2-(propylsulfanyl)-7-(trifluoromethyn-auinoline-3-carboxamide

209 mg (1.5 mmol) K₂CO₃ and 137 μl (1.5 mmol) propanethiol were added to a solution of 200 mg (0.5 mmol) 2-chloro-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide (VVV17) in DMF (4 ml) and the mixture was heated in a closed vessel for 72 h at 40° C. After cooling to RT the mixture was diluted with water and extracted with EE. The organic phase was washed with water and brine, dried over MgSO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 3:1) of the residue yielded 146 mg (0.33 mmol, 67%) N-[(3-fluorophenyl)-methyl]-4-methyl-2-(propylsulfanyl)-7-(trifluoromethyl)-quinoline-3-carboxamide. MS: m/z 437.1 [M+H]⁺.

Synthesis of Example Compound 112: 2-Ethylsulfanyl-N-[(2-hydroxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide

A solution of 350 mg (0.8 mmol) 2-ethylsulfanyl-N-[(2-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide (example 84) in DCM (10 ml) was cooled to 0° C. 500 μl (4.9 mmol) boron tribromide were added dropwise at this temperature. The mixture was then stirred for 90 min at room temperature. Then it was diluted with water and extracted with DCM. The organic phase was washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 4:1) of the residue yielded 240 mg (0.57 mmol, 70%) 2-ethylsulfanyl-N-[(2-hydroxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide. MS: m/z 421.1 [M+H]⁺.

Synthesis of Example Compound 122: 4-Chloro-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide

A mixture of 1.0 g (2.36 mmol) 2-(ethylthio)-N-(3-fluorobenzyl)-4-hydroxy-7-(trifluoromethyl)quinoline-3-carboxamide and POCl₃ (10 ml) was heated for 2 h at 130° C. After cooling to RT the mixture was adjusted to pH ˜8 with a saturated aqueous NaHCO₃ solution and extracted with EE. The organic phase was washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 22:3) of the residue yielded 0.5 g (1.1 mmol, 48%) 4-chloro-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide. MS: m/z 443.1 [M+H]⁺.

Synthesis of Example Compound 130: 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methoxy-7-(trifluoromethyl)-quinoline-3-carboxamide

20 mg (0.95 mmol) sodium were added to methanol (6 ml) at RT. Once the sodium had completely dissolved, a solution of 210 mg (0.47 mmol) 4-chloro-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide (example 122) in MeOH (2 ml) was added at RT. The mixture was then heated for 30 min at 60° C. Then the mixture was concentrated to small volume under vacuum and the residue was taken up with water and extracted with EE. The organic phase was washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 9:1) of the residue yielded 80 mg (0.18 mmol, 38%) 2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methoxy-7-(trifluoromethyl)-quinoline-3-carboxamide. MS: m/z 439.1 [M+H]⁺.

Synthesis of Example Compound 131: 4-Dimethylamino-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide

60 mg (0.45 mmol) K₂CO₃ and 0.7 ml (1.36 mmol, 2M in THF) dimethylamine were added at RT to a solution of 200 mg (0.45 mmol) 4-chloro-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide (example 122) in DMF (3 ml) and the mixture was then heated in a closed vessel for 150 min at 80°. Then it was diluted with water and extracted with EE. The organic phase was washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/EE 17:3) of the residue yielded 120 mg (0.27 mmol, 60%) 4-dimethylamino-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide. MS: m/z 452.1 [M+H]⁺.

Synthesis of Example Compound 132: 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyloxy)-quinoline-3-carboxamide

1.12 ml (2.24 mmol, 2M in toluene)trimethyl aluminium and 260 μl (2.24 mmol) 4-fluorobenzylamine were added in succession to a solution of 200 mg (0.56 mmol) 2-ethylsulfanyl-4-methyl-7-(trifluoromethyloxy)-quinoline-3-carboxylic acid ethyl ester (VVV25) in toluene (7 ml) and the mixture was then heated for 3 h at 90° C. Then it was diluted with 0.5M hydrochloric acid and extracted with EE. The organic phase was washed with water and brine, dried over Na₂SO₄, filtered and concentrated to small volume under vacuum. Column chromatography (hexane/DCM 3:2) of the residue yielded 150 mg (0.34 mmol, 61%) 2-ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyloxy)-quinoline-3-carboxamide. MS: m/z 439.1 [M+H]⁺.

Synthesis of Further Example Compounds

The synthesis of further example compounds took place by the methods already described. Table 2 shows which compound was prepared by which method. The starting materials and reagents used in each case are apparent to the person skilled in the art.

TABLE 2 Preparation MS Ex- analogous m/z am- to [M + ple Chemical name example H]⁺ 3 2-(3-Cyclohexyl-propylsulfanyl)-N- 1 425.2 (thiophen-2-yl-methyl)-quinoline-3- carboxamide 4 2-(3-Phenyl-propylsulfanyl)-N-(thiophen-2- 1 419.1 yl-methyl)-quinoline-3-carboxamide 6 2-[3-(4-Fluorophenyl)-propylsulfanyl]-N- 13 437.1 (thiophen-2-yl-methyl)-quinoline-3- carboxamide 9 2-[2-(Benzenesulfonyl)-ethylsulfanyl]-N- 5 537.1 (thiophen-2-yl-methyl)-7-(trifluoromethyl)- quinoline-3-carboxamide 10 2-[2-(Benzenesulfonyl)-ethylsulfanyl]-N- 5 537.1 (thiophen-2-yl-methyl)-5-(trifluoromethyl)- quinoline-3-carboxamide 12 2-Ethylsulfanyl-N-(thiophen-2-yl-methyl)- 11 397.1 6-(trifluoromethyl)-quinoline-3- carboxamide 14 2-Ethylsulfanyl-N-(thiophen-2-yl-methyl)- 11 397.1 7-(trifluoromethyl)-quinoline-3- carboxamide 15 2-(Pentylsulfanyl)-N-(thiophen-2-yl- 11 439.1 methyl)-7-(trifluoromethyl)-quinoline-3- carboxamide 16 2-[2-[(4-Fluorophenyl)sulfonyl]- 13 487.1 ethylsulfanyl]-N-(thiophen-2-yl-methyl)- quinoline-3-carboxamide 17 2-[2-(p-Tolylsulfonyl)-ethylsulfanyl]-N- 13 483.1 (thiophen-2-yl-methyl)-quinoline-3- carboxamide 18 2-[2-(p-Tolylsulfanyl)-ethylsulfanyl]-N- 13 451.1 (thiophen-2-yl-methyl)-quinoline-3- carboxamide 19 2-[2-(Benzenesulfonyl)-ethylsulfanyl]-N- 5 469.2 (cyclohexylmethyl)-quinoline-3- carboxamide 20 2-[3-(p-Tolyl)-propylsulfanyl]-N-(thiophen- 13 433.1 2-yl-methyl)-quinoline-3-carboxamide 21 2-(2-Phenylsulfanyl-ethylsulfanyl)-N- 13 437.1 (thiophen-2-yl-methyl)-quinoline-3- carboxamide 22 2-[2-(Benzenesulfonyl)-ethylsulfanyl]-N-(2- 5 483.2 cyclohexylethyl)-quinoline-3-carboxamide 23 2-[2-(Benzenesulfonyl)-ethylsulfanyl]-N- 5 457.2 (3,3-dimethylbutyl)-quinoline-3- carboxamide 24 2-[2-[(4-Fluorophenyl)sulfanyl]- 13 455.1 ethylsulfanyl]-N-(thiophen-2-yl-methyl)- quinoline-3-carboxamide 25 N-(3,3-Dimethylbutyl)-2-ethylsulfanyl-4- 8 399.2 methyl-7-(trifluoromethyl)-quinoline-3- carboxamide 26 3-[[3-(Thiophen-2-yl-methyl-carbamoyl)-6- 8 455.1 (trifluoromethyl)-quinolin-2-yl]sulfanyl]- propionic acid methyl ester 27 3-[[3-(Thiophen-2-yl-methyl-carbamoyl)-7- 2 455.1 (trifluoromethyl)-quinolin-2-yl]sulfanyl]- propionic acid methyl ester 28 N-(2,2-Dimethylpropyl)-2-ethylsulfanyl-4- 30 385.1 methyl-7-(trifluoromethyl)-quinoline-3- carboxamide 29 N-(Cycloheptylmethyl)-2-ethylsulfanyl-4- 30 425.2 methyl-7-(trifluoromethyl)-quinoline-3- carboxamide 31 N-[(3,4-Difluorophenyl)-methyl]-2- 30 441.1 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 32 N-[(2,4-Difluorophenyl)-methyl]-2- 30 441.1 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 33 2-Ethylsulfanyl-4-methyl-7- 30 459.1 (trifluoromethyl)-N-[(3,4,5-trifluorophenyl)- methyl]-quinoline-3-carboxamide 34 2-Ethylsulfanyl-4-methyl-7- 30 459.1 (trifluoromethyl)-N-[(2,4,5-trifluorophenyl)- methyl]-quinoline-3-carboxamide 35 2-Ethylsulfanyl-4-methyl-N-(pyridin-4-yl- 30 406.1 methyl)-7-(trifluoromethyl)-quinoline-3- carboxamide 36 N-[(4-tert-Butylphenyl)-methyl]-2- 30 461.2 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 37 2-Ethylsulfanyl-4-methyl-N-(3- 30 385.1 methylbutyl)-7-(trifluoromethyl)-quinoline- 3-carboxamide 38 2-Ethylsulfanyl-4-methyl-7- 30 473.1 (trifluoromethyl)-N-[[3- (trifluoromethyl)phenyl]-methyl]-quinoline- 3-carboxamide 39 2-Ethylsulfanyl-4-methyl-N-phenethyl-7- 30 419.1 (trifluoromethyl)-quinoline-3-carboxamide 40 2-Ethylsulfanyl-4-methyl-N-(3- 30 433.1 phenylpropyl)-7-(trifluoromethyl)- quinoline-3-carboxamide 41 2-Ethylsulfanyl-4-methyl-N-(pyridin-2-yl- 30 406.1 methyl)-7-(trifluoromethyl)-quinoline-3- carboxamide 42 2-Ethylsulfanyl-4-methyl-N-(pyridin-3-yl- 30 406.1 methyl)-7-(trifluoromethyl)-quinoline-3- carboxamide 43 2-Ethylsulfanyl-4-methyl-N-(naphthalen-2- 30 455.1 yl-methyl)-7-(trifluoromethyl)-quinoline-3- carboxamide 44 2-Ethylsulfanyl-4-methyl-N-(thiazol-2-yl- 30 412.1 methyl)-7-(trifluoromethyl)-quinoline-3- carboxamide 45 2-Ethylsulfanyl-4-methyl-N- 30 397.1 ([1,3,4]oxadiazol-2-yl-methyl)-7- (trifluoromethyl)-quinoline-3-carboxamide 47 N-[(3-Fluorophenyl)-methyl]-2- 46 437.1 (isopropylsulfanyl)-4-methyl-7- (trifluoromethyl)-quinoline-3-carboxamide 48 2-(Cyclopentylsulfanyl)-N-[(3- 46 463.1 fluorophenyl)-methyl]-4-methyl-7- (trifluoromethyl)-quinoline-3-carboxamide 49 2-(Butylsulfanyl)-N-[(3-fluorophenyl)- 46 451.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 50 N-[(3-Fluorophenyl)-methyl]-4-methyl-2- 46 465.2 (pentylsulfanyl)-7-(trifluoromethyl)- quinoline-3-carboxamide 51 N-[(3-Fluorophenyl)-methyl]-4-methyl-2- 46 451.1 (1-methyl-propylsulfanyl)-7- (trifluoromethyl)-quinoline-3-carboxamide 52 2-(Cyclohexylsulfanyl)-N-[(3-fluorophenyl)- 46 477.2 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 53 N-(2-Cyclopentylethyl)-2-ethylsulfanyl-4- 30 411.2 methyl-7-(trifluoromethyl)-quinoline-3- carboxamide 54 N-(3-Cyclopentylpropyl)-2-ethylsulfanyl-4- 30 425.2 methyl-7-(trifluoromethyl)-quinoline-3- carboxamide 55 2-Ethylsulfanyl-4-methyl-7- 30 473.1 (trifluoromethyl)-N-[[4-(trifluoromethyl)- phenyl]-methyl]-quinoline-3-carboxamide 56 N-[(3-tert-Butylphenyl)-methyl]-2- 30 461.2 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 57 2-Ethylsulfanyl-4-methyl-N-(4- 30 399.2 methylpentyl)-7-(trifluoromethyl)-quinoline- 3-carboxamide 58 2-Benzylsulfanyl-N-[(3-fluorophenyl)- 46 485.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 59 2-Ethylsulfanyl-N-[(3-fluoro-2- 30 453.1 methoxyphenyl)-methyl]-4-methyl-7- (trifluoromethyl)-quinoline-3-carboxamide 60 2-Ethylsulfanyl-N-[(5-fluoro-2- 30 453.1 methoxyphenyl)-methyl]-4-methyl-7- (trifluoromethyl)-quinoline-3-carboxamide 61 N-[(3,4-Dimethylphenyl)-methyl]-2- 30 433.1 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 62 2-Ethylsulfanyl-4-methyl-7- 30 505.1 (trifluoromethyl)-N-[[4- (trifluoromethylsulfanyl)-phenyl]methyl]- quinoline-3-carboxamide 63 N-(Cyclohexylmethyl)-2-ethylsulfanyl-4- 30 411.2 methyl-7-(trifluoromethyl)-quinoline-3- carboxamide 64 2-Ethylsulfanyl-4-methyl-N- 30 413.1 (tetrahydropyran-2-yl-methyl)-7- (trifluoromethyl)-quinoline-3-carboxamide 65 2-Ethylsulfanyl-4-methyl-N-propyl-7- 30 357.1 (trifluoromethyl)-quinoline-3-carboxamide 66 N-Butyl-2-ethylsulfanyl-4-methyl-7- 30 371.1 (trifluoromethyl)-quinoline-3-carboxamide 67 2-Ethylsulfanyl-N-(2-methoxyethyl)-4- 30 373.1 methyl-7-(trifluoromethyl)-quinoline-3- carboxamide 68 2-Ethylsulfanyl-4-methyl-N-pentyl-7- 30 385.1 (trifluoromethyl)-quinoline-3-carboxamide 69 2-Ethylsulfanyl-4-methyl-N-[(5- 30 425.1 methylthiophen-2-yl)-methyl]-7- (trifluoromethyl)-quinoline-3-carboxamide 70 2-Ethylsulfanyl-4-methyl-N-[(4- 30 425.1 methylthiophen-2-yl)-methyl]-7- (trifluoromethyl)-quinoline-3-carboxamide 71 N-[(5-Chlorothiophen-2-yl)-methyl]-2- 30 445 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 72 2-Ethylsulfanyl-4-methyl-N-(2-thiophen-2- 30 425.1 yl-ethyl)-7-(trifluoromethyl)-quinoline-3- carboxamide 73 N-(5-Bicyclo[2.2.1]heptanylmethyl)-2- 30 423.2 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 74 N-Benzyl-2-ethylsulfanyl-4-methyl-7- 30 405.1 (trifluoromethyl)-quinoline-3-carboxamide 75 2-Ethylsulfanyl-N-[(2-fluorophenyl)- 30 423.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 76 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 30 423.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 77 2-Ethylsulfanyl-N-[(4-fluorophenyl)- 30 423.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 78 N-[(2-Chlorophenyl)-methyl]-2- 30 439.1 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 79 N-[(3-Chlorophenyl)-methyl]-2- 30 439.1 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 80 N-[(4-Chlorophenyl)-methyl]-2- 30 439.1 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 81 2-Ethylsulfanyl-4-methyl-N-(o-tolylmethyl)- 30 419.1 7-(trifluoromethyl)-quinoline-3- carboxamide 82 2-Ethylsulfanyl-4-methyl-N-(m- 30 419.1 tolylmethyl)-7-(trifluoromethyl)-quinoline-3- carboxamide 83 2-Ethylsulfanyl-4-methyl-N-(p-tolylmethyl)- 30 419.1 7-(trifluoromethyl)-quinoline-3- carboxamide 84 2-Ethylsulfanyl-N-[(2-methoxyphenyl)- 30 435.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 85 2-Ethylsulfanyl-N-[(3-methoxyphenyl)- 30 435.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 86 2-Ethylsulfanyl-N-[(4-methoxyphenyl)- 30 435.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 87 N-[(3,5-Difluorophenyl)-methyl]-2- 30 441.1 ethylsulfanyl-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 88 4-Methyl-2-methylsulfanyl-N-(thiophen-2- 30 397.1 yl-methyl)-7-(trifluoromethyl)-quinoline-3- carboxamide 89 2-(tert-Butylsulfanyl)-4-methyl-N- 30 439.1 (thiophen-2-yl-methyl)-7-(trifluoromethyl)- quinoline-3-carboxamide 90 N-(2,2-Dimethylpropyl)-2-ethylsulfanyl-7- 30 371.1 (trifluoromethyl)-quinoline-3-carboxamide 91 2-Ethylsulfanyl-4-methyl-N-(thiophen-2-yl- 30 343.1 methyl)-quinoline-3-carboxamide 92 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 30 355.1 methyl]-4-methyl-quinoline-3-carboxamide 93 2-(tert-Butylsulfanyl)-N-[(3-fluorophenyl)- 30 451.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 94 2-(tert-Butylsulfanyl)-N-[(4-fluorophenyl)- 30 451.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 95 7-tert-Butyl-2-ethylsulfanyl-N-[(3- 30 411.2 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 96 7-tert-Butyl-2-ethylsulfanyl-N-[(4- 30 411.2 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 97 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 30 385.1 methyl]-7-methoxy-4-methyl-quinoline-3- carboxamide 98 2-Ethylsulfanyl-N-[(4-fluorophenyl)- 30 385.1 methyl]-7-methoxy-4-methyl-quinoline-3- carboxamide 99 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 30 369.1 methyl]-4,6-dimethyl-quinoline-3- carboxamide 100 2-Ethylsulfanyl-N-[(4-fluorophenyl)- 30 369.1 methyl]-4,6-dimethyl-quinoline-3- carboxamide 101 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 30 385.1 methyl]-6-methoxy-4-methyl-quinoline-3- carboxamide 102 2-Ethylsulfanyl-N-[(4-fluorophenyl)- 30 385.1 methyl]-6-methoxy-4-methyl-quinoline-3- carboxamide 103 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 30 423.1 methyl]-4-methyl-6-(trifluoromethyl)- quinoline-3-carboxamide 104 2-Ethylsulfanyl-N-[(4-fluorophenyl)- 30 423.1 methyl]-4-methyl-6-(trifluoromethyl)- quinoline-3-carboxamide 105 2-Ethylsulfanyl-7-fluoro-N-[(3- 30 373.1 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 106 2-Ethylsulfanyl-7-fluoro-N-[(4- 30 373.1 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 107 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 30 369.1 methyl]-4,7-dimethyl-quinoline-3- carboxamide 108 2-Ethylsulfanyl-N-[(4-fluorophenyl)- 30 369.1 methyl]-4,7-dimethyl-quinoline-3- carboxamide 109 2-Ethylsulfanyl-6,7-difluoro-N-[(4- 30 391.1 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 110 2-Ethylsulfanyl-N-(furan-2-yl-methyl)-4- 30 395.1 methyl-7-(trifluoromethyl)-quinoline-3- carboxamide 111 2-Ethylsulfanyl-4-methyl-N-[(5-methyl- 30 409.1 furan-2-yl)-methyl]-7-(trifluoromethyl)- quinoline-3-carboxamide 113 2-Ethylsulfanyl-N-[(3-hydroxyphenyl)- 112 421.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 114 N-[(3-Fluorophenyl)-methyl]-4-methyl-2- 30 409.1 methylsulfanyl-7-(trifluoromethyl)- quinoline-3-carboxamide 115 N-[(4-Fluorophenyl)-methyl]-4-methyl-2- 30 409.1 methylsulfanyl-7-(trifluoromethyl)- quinoline-3-carboxamide 116 2-Ethylsulfanyl-6-fluoro-N-[(3- 30 373.1 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 117 2-Ethylsulfanyl-6-fluoro-N-[(4- 30 373.1 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 118 2-Ethylsulfanyl-6,7-difluoro-N-[(3- 30 391.1 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 119 2-Ethylsulfanyl-N-[(4-hydroxyphenyl)- 112 421.1 methyl]-4-methyl-7-(trifluoromethyl)- quinoline-3-carboxamide 120 2-Ethylsulfanyl-8-fluoro-N-[(3- 30 373.1 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 121 2-Ethylsulfanyl-8-fluoro-N-[(4- 30 373.1 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 123 2-Ethylsulfanyl-5-fluoro-N-[(3- 30 373.1 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 124 2-Ethylsulfanyl-5-fluoro-N-[(4- 30 373.1 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 125 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 30 385.1 methyl]-5-methoxy-4-methyl-quinoline-3- carboxamide 126 2-Ethylsulfanyl-N-[(4-fluorophenyl)- 30 385.1 methyl]-5-methoxy-4-methyl-quinoline-3- carboxamide 127 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 112 371.1 methyl]-5-hydroxy-4-methyl-quinoline-3- carboxamide 128 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 112 371.1 methyl]-6-hydroxy-4-methyl-quinoline-3- carboxamide 129 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 112 371.1 methyl]-7-hydroxy-4-methyl-quinoline-3- carboxamide 133 7-Dimethylamino-2-ethylsulfanyl-N-[(4- 132 398.2 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 134 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 30 440.2 methyl]-4-methyl-7-morpholin-4-yl- quinoline-3-carboxamide 135 2-Ethylsulfanyl-N-[(4-fluorophenyl)- 30 440.2 methyl]-4-methyl-7-morpholin-4-yl- quinoline-3-carboxamide 136 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 132 423.1 methyl]-4-methyl-8-(trifluoromethyl)- quinoline-3-carboxamide 137 2-Ethylsulfanyl-N-[(4-fluorophenyl)- 132 423.1 methyl]-4-methyl-8-(trifluoromethyl)- quinoline-3-carboxamide 138 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 132 385.1 methyl]-8-methoxy-4-methyl-quinoline-3- carboxamide 139 2-Ethylsulfanyl-N-[(4-fluorophenyl)- 132 385.1 methyl]-8-methoxy-4-methyl-quinoline-3- carboxamide 140 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 112 371.1 methyl]-8-hydroxy-4-methyl-quinoline-3- carboxamide 141 7-Dimethylamino-2-ethylsulfanyl-N-[(3- 132 398.2 fluorophenyl)-methyl]-4-methyl-quinoline- 3-carboxamide 142 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 132 439.1 methyl]-4-methyl-7-(trifluoromethyloxy)- quinoline-3-carboxamide 143 4-Ethyl-2-ethylsulfanyl-N-[(3- 30 437.1 fluorophenyl)-methyl]-7-(trifluoromethyl)- quinoline-3-carboxamide 144 2-Ethylsulfanyl-N-[(3-fluorophenyl)- 30 451.1 methyl]-4-isopropyl-7-(trifluoromethyl)- quinoline-3-carboxamide

Pharmacological Experiments Fluorescence Assay Using a Voltage-Sensitive Dye

Human CHO-K1 cells expressing KCNQ2/3 channels are cultivated adherently at 37° C., 5% CO₂ and 95% humidity in cell culture bottles (e.g. 80 cm² TC flasks, Nunc) with DMEM-high glucose (Sigma Aldrich, D7777) including 10% FCS (PAN Biotech, e.g. 3302-P270521) or alternatively MEM Alpha Medium (1×, liquid, Invitrogen, #22571), 10% foetal calf serum (FCS) (Invitrogen, #10270-106, heat-inactivated) and the necessary selection antibiotics.

Before being seeded out for the measurements, the cells are washed with a 1×DPBS buffer without Ca²⁺/Mg²⁺ (e.g. Invitrogen, #14190-094) and detached from the bottom of the culture vessel by means of Accutase (PAA Laboratories, #L11-007) (incubation with Accutase for 15 min at 37° C.). The cell count then present is determined using a CASY™ cell counter (TCC model, Scharfe System) in order subsequently to apply 20,000 to 30,000 cells/well/100 μl of the described nutrient medium, depending on density optimisation for the individual cell line, to 96-well measuring plates of the Corning™ CeIIBIND™ type (flat clear-bottom black polystyrene microplates, #3340). Incubation is then carried out for one hour at room temperature, without gassing or adjusting the humidity, followed by incubation for 24 hours at 37° C., 5% CO₂ and 95% humidity.

The voltage-sensitive fluorescent dye from the Membrane Potential Assay Kit (Red™ bulk format part R8123 for FLIPR, MDS Analytical Technologies™) is prepared by dissolving the contents of a vessel of Membrane Potential Assay Kit Red Component A in 200 ml of extracellular buffer (ES buffer, 120 mM NaCl, 1 mM KCl, 10 mM HEPES, 2 mM CaCl₂, 2 mM MgCl₂, 10 mM glucose; pH 7.4). After removal of the nutrient medium, the cells are washed with 200 μl of ES buffer, then covered with a layer of 100 μl of the dye solution prepared above and incubated for 45 min at room temperature with exclusion of light.

The fluorescence measurements are carried out with a BMG Labtech FLUOstar™, BMG Labtech NOVOstar™ or BMG Labtech POLARstar™ instrument (525 nm excitation, 560 nm emission, bottom-read mode). After incubation of the dye, 50 μl of the substances to be tested in the desired concentrations, or 50 μl of ES buffer for control purposes, are introduced into separate cavities of the measuring plate and incubated for 30 min at room temperature whilst being shielded from light. The fluorescence intensity of the dye is then measured for 5 min and the fluorescence value F₁ of each well is thus determined at a given, constant time. 15 μl of a 100 mM KCl solution (final concentration 92 mM) are then added to each well. The change in fluorescence is subsequently measured until all relevant measured values have been obtained (mainly 5-30 min). At a given time after KCl application, a fluorescence value F₂ is determined, in this case at the time of the fluorescence peak.

For calculation, the fluorescence intensity F₂ is compared with the fluorescence intensity F₁, and the agonistic activity of the target compound on the potassium channel is determined therefrom. F₂ and F₁ are calculated as follows:

${\left( \frac{F_{2} - F_{1}}{F_{1}} \right) \times 100} = {\frac{\Delta \; F}{F}(\%)}$

In order to determine whether a substance has an agonistic activity,

$\frac{\Delta \; F}{F},$

for example, can be compared with

$\left( \frac{\Delta \; F}{F} \right)_{K}$

of control cells.

$\left( \frac{\Delta \; F}{F} \right)_{K}$

is determined by adding to the reaction batch only the buffer solution instead of the substance to be tested, determining the value F_(1K) of the fluorescence intensity, adding the potassium ions as described above and measuring a value F_(2K) of the fluorescence intensity. Then F_(2K) and F_(1K) are calculated as follows:

${\left( \frac{F_{2K} - F_{1K}}{F_{1K}} \right) \times 100} = {\left( \frac{\Delta \; F}{F} \right)_{K}(\%)}$

A substance has an agonistic activity on the potassium channel if

$\frac{\Delta \; F}{F}$

is greater than

$\left( \frac{\Delta \; F}{F} \right)_{K:}$

${\frac{\Delta \; F}{F}\rangle}\left( \frac{\Delta \; F}{F} \right)_{K}$

Independently of the comparison of

${\frac{\Delta \; F}{F}\mspace{14mu} {with}\mspace{14mu} \left( \frac{\Delta \; F}{F} \right)_{K}},$

it is also possible to conclude that a target compound has an agonistic activity if an increase in

$\frac{\Delta \; F}{F}$

is to be observed as the dosage of the target compound increases.

Calculations of EC₅₀ values are carried out with the aid of Prism v4.0 software (GraphPad Software™).

Low-Intensity Tail Flick in Rats

The antinociceptive activity of the test substance against an acute noxic thermal stimulant was examined in the tail-flick test in rats using the method described by D′Amour and Smith (J. Pharm. Exp. Ther. 72, 74 79 (1941)). Male Sprague-Dawley rats weighing between 200 and 250 g were used (breeder: Janvier, Le Genest St. Isle, France). The animals were placed in special test compartments and the base of the tail was exposed to a focused light beam from an analgesia meter (model 2011, Rhema Labortechnik, Hofheim, Germany). 10 animals were used per group. Before administering a substance according to the invention, the tail-flick latency (time from switching on the light beam to the flick of the tail) was measured twice at an interval of five minutes and the average was defined as the control latency time. The intensity of the light beam was chosen so that the control latency time was 7 to 9 seconds.

The measurement of the tail-flick latency was then repeated 10, 20, 30 and 60 minutes after peroral administration of the substance. The antinociceptive action of the test substance was determined as the increase in the tail-flick latency time using the following formula:

MPE[%]=[(T ₁ −T ₀)/(T ₂ −T ₀)]×100

where T₀=control latency time before administration of the substance, T₁=latency time after administration of the substance, T₂=maximum exposure time to the light beam (30 seconds), MPE=maximum possible effect.

Analysis of variance (repeated measures ANOVA) was used to test for statistically significant differences between the substance and vehicle group. The significance level was set at ≦0.05.

Pharmacological Data

The results of the pharmacological models described above are summarised in Table 3.

TABLE 3 Low- Fluorimetry intensity % efficacy tail flick at 1 μM rat p.o. Fluorimetry (50 μM % effect Example EC50 retigabine = (dose compound [nM] 100%) [mg/kg]) 1 744 143 2 26 3 1931 77 4 144 168 5 2657 98 6 1221 111 7 1350 8 46 9 26 10 9 11 41 12 412 155 13 991 136 14 291 223 9 (21.5) 15 778 145 16 78 164 17 77 18 72 19 167 71 20 64 21 119 30 22 15 23 14 24 27 25 8 28 47 29 367 86 30 82 141 31 (10)   31 145 159 32 59 70 33 140 162 34 98 72 35 2655 142 36 136 93 37 85 121 0 (10.0) 38 76 142 39 473 48 40 194 152 41 1105 121 42 1690 175 51 (21.5)  43 159 77 44 587 169 45 23 46 141 155 47 73 152 48 56 133 49 74 151 50 61 150 51 37 158 52 64 102 53 256 73 54 162 229 55 149 167 56 67 97 57 150 205 69 858 123 70 1463 114 71 305 163 72 732 59 73 25 74 163 128 75 71 88 76 92 182 ED₅₀ 6.3 77 105 137 37 (10)   78 33 79 124 116 80 148 135 81 28 82 219 108 83 242 130 84 25 85 413 89 86 565 108 87 144 159 88 212 154 89 64 220 ED₅₀ 2.7 90 842 53 91 1213 50 92 950 65 93 88 157 94 54 162 71 (4.64)  95 627 96 96 808 101 97 622 60 98 404 70 99 623 90 100 337 45 101 17 102 14 103 784 115 104 25 105 248 140 106 216 143 107 499 161 108 509 149 109 187 144 7 (10.0) 110 89 183 111 86 178 112 130 211 17 (10.0)  113 3992 66 114 169 175 115 136 150 116 598 147 117 222 87 118 147 149 119 2748 72 120 1212 157 121 334 90 122 65 171 123 8 124 8 125 14 126 5 127 18 128 39 129 12 130 58 180 131 1818 104 132 51 161 133 15 134 21 135 6 136 227 164 137 225 166 138 2235 91 139 1958 91 140 1150 101

4-OH-2-Mercapto-quinoline-3-carboxamides are known from FR2532939 for which a pharmacological action in a pain model and in an inflammatory model are described, without specifying a mechanism of action.

Recreations of the teaching of FR2532939 show, however, that such 2-mercapto-quinoline-3-carboxamides having a 4-hydroxy function have no effect in the pharmacological model in the fluorescence assay on KCNQ2/3 up to concentrations in the relevant range up to 30 mmol.

In the compounds according to the invention according to claim a 4-hydroxy function is excluded by an appropriate definition of R⁵. 

1. A substituted 2-mercaptoquinoline-3-carboxamide having the general formula (1):

wherein R⁰ stands for C₁₋₁₀ alkyl or C₂₋₁₀ heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted; C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted; C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted, wherein the alkyl or heteroalkyl chain can in each case be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted, wherein the alkyl or heteroalkyl chain can in each case be branched or unbranched, saturated or unsaturated, unsubstituted, mono- or polysubstituted; R¹, R², R³, R⁴ each denote independently of one another H; F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)H; C(═O)R⁰; CO₂H; C(═O)OR⁰; CONH₂; C(═O)NHR⁰; C(═O)N(R⁰)₂; OH; OR⁰; O—C(═O)—R⁰; O—C(═O)—O—R⁰; O—(C═O)—NH—R⁰; O—C(═O)—N(R⁰)₂; O—S(═O)₂—R⁰; O—S(═O)₂OH; O—S(═O)₂OR⁰; O—S(═O)₂NH₂; O—S(═O)₂NHR⁰; O—S(═O)₂N(R⁰)₂; NH₂; NH—R⁰; N(R⁰)₂; NH—C(═O)—R⁰; NH—C(═O)—O—R⁰; NH—C(═O)—NH₂; NH—C(═O)—NH—R⁰; NH—C(═O)—N(R⁰)₂; NR⁰—C(═O)—R⁰; NR⁰—C(═O)—O—R⁰; NR⁰—C(═O)—NH₂; NR⁰—C(═O)—NH—R⁰; NR⁰—C(═O)—N(R⁰)₂; NH—S(═O)₂OH; NH—S(═O)₂R⁰; NH—S(═O)₂OR⁰; NH—S(═O)₂NH₂; NH—S(═O)₂NHR⁰; NH—S(═O)₂N(R⁰)₂; NR⁰—S(═O)₂OH; NR⁰—S(═O)₂R⁰; NR⁰—S(═O)₂OR⁰; NR⁰—S(═O)₂NH₂; NR⁰—S(═O)₂NHR⁰; NR⁰—S(═O)₂N(R⁰)₂; SH; SR⁰; S(═O)R⁰; S(═O)₂R⁰; S(═O)₂OH; S(═O)₂OR⁰; S(═O)₂NH₂; S(═O)₂NHR⁰; or S(═O)₂N(R⁰)₂; R⁵ stands for H; F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)H; C(═O)R⁰; CO₂H; C(═O)OR⁰; CONH₂; C(═O)NHR⁰; C(═O)N(R⁰)₂; OR⁰; O—C(═O)—R⁰; O—C(═O)—O—R⁰; O—(C═O)—NH—R⁰; O—C(═O)—N(R⁰)₂; O—S(═O)₂—R⁰; O—S(═O)₂OH; O—S(═O)₂OR⁰; O—S(═O)₂NH₂; O—S(═O)₂NHR⁰; O—S(═O)₂N(R⁰)₂; NH₂; NH—R⁰; N(R⁰)₂; NH—C(═O)—R⁰; NH—C(═O)—O—R⁰; NH—C(═O)—NH₂; NH—C(═O)—NH—R⁰; NH—C(═O)—N(R⁰)₂; NR⁰—C(═O)—R⁰; NR⁰—C(═O)—O—R⁰; NR⁰—C(═O)—NH₂; NR⁰—C(═O)—NH—R⁰; NO—C(═O)—N(O)₂; NH—S(═O)₂OH; NH—S(═O)₂R⁰; NH—S(═O)₂OR⁰; NH—S(═O)₂NH₂; NH—S(═O)₂NHR⁰; NH—S(═O)₂N(R)₂; NR⁰—S(═O)₂OH; NR⁰—S(═O)₂R⁰; NR⁰—S(═O)₂OR⁰; NR⁰—S(═O)₂NH₂; NR⁰—S(═O)₂NHR⁰; NR⁰—S(═O)₂N(R⁰)₂; SH; SR⁰; S(═O)R⁰; S(═O)₂R⁰; S(═O)₂OH; S(═O)₂OR⁰; S(═O)₂NH₂; S(═O)₂NHR⁰; or S(═O)₂N(R⁰)₂; R⁶ stands for R⁰, with the proviso that if R⁰ denotes heterocyclyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted, or heteroaryl, unsubstituted or mono- or polysubstituted, then of the heteroaryl or heterocyclyl is bound via a carbon atom of the heteroaryl or heterocyclyl; R⁷ stands for R⁰, with the proviso that if R⁰ denotes heterocyclyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted, or heteroaryl, unsubstituted or mono- or polysubstituted, then the heteroaryl or heterocyclyl is bound via a carbon atom of the heteroaryl or heterocyclyl; wherein “substituted” in the case of substitution on alkyl, heteroalkyl, heterocyclyl and cycloalkyl stands for the substitution of one or more hydrogen atoms, each independently of one another, with F; Cl; Br; I; CN; CF₃; ═O; ═NH; ═C(NH₂)₂; NO₂; R⁰; C(═O)H; C(═O)R⁰; CO₂H; C(═O)OR⁰; CONH₂; C(═O)NHR⁰; C(═O)N(R⁰)₂; OH; OR⁰; —O—(C₁₋₈ alkyl)-O—; O—C(═O)—R⁰; O—C(═O)—O—R⁰; O—(C═O)—NH—R⁰; O—C(═O)—N(R⁰)₂; O—S(═O)₂—R⁰; O—S(═O)₂OH; O—S(═O)₂OR⁰; O—S(═O)₂NH₂; O—S(═O)₂NHR⁰; O—S(═O)₂N(R⁰)₂; NH₂; NH—R⁰; N(R⁰)₂; NH—C(═O)—R⁰; NH—C(═O)—O—R⁰; NH—C(═O)—NH₂; NH—C(═O)—NH—R⁰; NH—C(═O)—N(R⁰)₂; NR⁰—C(═O)—R⁰; NR⁰—C(═O)—O—R⁰; NR⁰—C(═O)—NH₂; NR⁰—C(═O)—NH—R⁰; NR⁰—C(═O)—N(R⁰)₂; NH—S(═O)₂OH; NH—S(═O)₂R⁰; NH—S(═O)₂OR⁰; NH—S(═O)₂NH₂; NH—S(═O)₂NHR⁰; NH—S(═O)₂N(R⁰)₂; NR⁰—S(═O)₂OH; NR⁰—S(═O)₂R⁰; NR⁰—S(═O)₂OR⁰; NR⁰—S(═O)₂NH₂; NR⁰—S(═O)₂NHR⁰; NR⁰—S(═O)₂N(R⁰)₂; SH; SR⁰; S(═O)R⁰; S(═O)₂R⁰; S(═O)₂H; S(═O)₂OH; S(═O)₂OR⁰; S(═O)₂NH₂; S(═O)₂NHR⁰; or S(═O)₂N(R)₂; wherein “substituted” in the case of substitution on aryl and heteroaryl stands for the substitution of one or more hydrogen atoms, each independently of one another, with F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)H; C(═O)R⁰; CO₂H; C(═O)OR⁰; CONH₂; C(═O)NHR⁰; C(═O)N(R⁰)₂; OH; OR⁰; —O—(C₁₋₈ alkyl)-O—; O—C(═O)—R⁰; O—C(═O)—O—R⁰; O—(C═O)—NH—R⁰; O—C(═O)—N(R⁰)₂; O—S(═O)₂—R⁰; O—S(═O)₂OH; O—S(═O)₂OR⁰; O—S(═O)₂NH₂; O—S(═O)₂NHR⁰; O—S(═O)₂N(R⁰)₂; NH₂; NH—R⁰; N(R⁰)₂; NH—C(═O)—R⁰; NH—C(═O)—O—R⁰; NH—C(═O)—NH₂; NH—C(═O)—NH—R⁰; NH—C(═O)—N(R⁰)₂; NR⁰—C(═O)—R⁰; NR⁰—C(═O)—O—R⁰; NR⁰—C(═O)—NH₂; NR⁰—C(═O)—NH—R⁰; NR⁰—C(═O)—N(R⁰)₂; NH—S(═O)₂OH; NH—S(═O)₂R⁰; NH—S(═O)₂OR⁰; NH—S(═O)₂NH₂; NH—S(═O)₂NHR⁰; NH—S(═O)₂N(R⁰)₂; NR⁰—S(═O)₂OH; NR⁰—S(═O)₂R⁰; NR⁰—S(═O)₂OR⁰; NR⁰—S(═O)₂NH₂; NR⁰—S(═O)₂NHR⁰; NR⁰—S(═O)₂N(R⁰)₂; SH; SR⁰; S(═O)R⁰; S(═O)₂R⁰; S(═O)₂OH; S(═O)₂OR⁰; S(═O)₂NH₂; S(═O)₂NHR⁰; or S(═O)₂N(R⁰)₂; with the exception of the following compound: N-benzyl-2-(3-chloro-2-hydroxypropylthio)-4-(2,4-dichlorophenyl)quinoline-3-carboxamide; said substituted 2-mercaptoquinoline-3-carboxamide being in the form of a free compound or a salt of physiologically compatible acids or bases.
 2. Substituted carboxamide according to claim 1, wherein R¹, R², R³ and R⁴ are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)(R⁰ or H); C(═O)O(R⁰ or H); C(═O)N(R⁰ or H)₂; OH; OR⁰; O—(C₁₋₈ alkyl)-OH; O—(C₁₋₈ alkyl)-O—C₁₋₈ alkyl; OCF₃; O—C(═O)—R⁰; N(R⁰ or H)₂; N(R⁰ or H)—C(═O)—R⁰; N(R⁰ or H)—C(═O)—N(R⁰ or H)₂; SH; SCF₃; SR⁰; S(═O)₂R⁰; S(═O)₂O(R⁰ or H) and S(═O)₂—N(R⁰ or H)₂; R⁵ is selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; C(═O)(R⁰ or H); C(═O)O(R⁰ or H); C(═O)N(R⁰ or H)₂; N(R⁰ or H)₂; N(R⁰ or H)—C(═O)—R⁰; N(R⁰ or H)—C(═O)—N(R⁰ or H)₂; SH; SCF₃; SR⁰; S(═O)₂R⁰; S(═O)₂O(R⁰ or H); and S(═O)₂—N(R⁰ or H)₂; R⁶ stands for C₁₋₁₀ alkyl or C₂₋₁₀ heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀ cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃, and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂, C₃₋₁₀ cycloalkyl or heterocyclyl or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, ═O, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃ and S(═O)₂OH; and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀ cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃, and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂; or aryl or heteroaryl or C₁₋₇₃ alkyl- or C₂₋₈ heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃ and S(═O)₂OH; and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀ cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃, and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂; and R⁷ stands for C₁₋₁₀ alkyl or C₂₋₁₀ heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀ cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃, and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂; C₃₋₁₀ cycloalkyl or heterocyclyl or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, ═O, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl, and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃; S(═O)₂OH; and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀ cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃, and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂; or aryl or heteroaryl or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl, and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃ and S(═O)₂OH; and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀ cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃; and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂.
 3. Substituted carboxamide according to claim 1, wherein R¹, R², R³ and R⁴ are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)(R⁰ or H); C(═O)O(R⁰ or H); C(═O)N(R⁰ or H)₂; OH; OR⁰; O—(C₁₋₈ alkyl)-OH; O—(C₁₋₈ alkyl)-O—C₁₋₈ alkyl; OCF₃; O—C(═O)—R⁰; N(R⁰ or H)₂; N(R⁰ or H)—C(═O)—R⁰; N(R⁰ or H)—C(═O)—N(R⁰ or H)₂; SH; SCF₃; SR⁰; S(═O)₂R⁰; S(═O)₂O(R⁰ or H); and S(═O)₂—N(R⁰ or H)₂; and R⁵ is selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; R⁰; C(═O)(R⁰ or H); C(═O)O(R⁰ or H); C(═O)N(R⁰ or H)₂; OR⁰; —O—(C₁₋₈ alkyl)-OH; O—(C₁₋₈ alkyl)-O—C₁₋₈ alkyl; OCF₃; O—C(═O)-e; N(R⁰ or H)₂; N(R⁰ or H)—C(═O)—R⁰; N(R⁰ or H)—C(═O)—N(R⁰ or H)₂; SH; SCF₃; SR⁰; S(═O)₂R⁰; S(═O)₂O(R⁰ or H); and S(═O)₂—N(R⁰ or H)₂.
 4. Substituted carboxamide according to claim 1, wherein, R¹, R², R³ and R⁴ are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; C(═O)H; C(═O)—OH; C(═O)—NH₂; C₁₋₈ alkyl, O—C₁₋₈ alkyl, C(═O)C₁₋₈ alkyl, C(═O)O—C₁₋₈ alkyl, O—C(═O)—C₁₋₈ alkyl, C(═O)NH—C₁₋₈ alkyl, C(═O)N(C₁₋₈ alkyl)₂, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, NH—C(═O)C₁₋₈ alkyl, N(C₁₋₈ alkyl)-C(═O)C₁₋₈ alkyl, S—C₁₋₈ alkyl, S(═O)₂C₁₋₈ alkyl, and S(═O)₂O—C₁₋₈ alkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O-methyl and OH; OH; OCF₃; SH; SCF₃; S(═O)₂OH; NH₂; C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted; benzyl, phenyl, pyridyl or thienyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, NH₂, CN, C₁₋₈ alkyl, O—C₁₋₈ alkyl, CF₃, OH, OCF₃, C(═O)—OH, SCF₃ and S(═O)₂OH; and R⁵ is selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; C(═O)H; C(═O)—OH; C(═O)—NH₂; C₁₋₈ alkyl, O—C₁₋₈ alkyl, C(═O)C₁₋₈ alkyl, C(═O)O—C₁₋₈ alkyl, O—C(═O)—C₁₋₈ alkyl, C(═O)NH—C₁₋₈ alkyl, C(═O)N(C₁₋₈ alkyl)₂, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, NH—C(═O)C₁₋₈ alkyl, N(C₁₋₈ alkyl)-C(═O)C₁₋₈ alkyl, S—C₁₋₈ alkyl, S(═O)₂C₁₋₈ alkyl, and S(═O)₂O—C₁₋₈ alkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O-methyl and OH; OCF₃; SH; SCF₃; S(═O)₂OH; NH₂; C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted; benzyl, phenyl, pyridyl or thienyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, NH₂, CN, C₁₋₈ alkyl, O—C₁₋₈ alkyl, CF₃, OH, OCF₃, C(═O)—OH, SCF₃ and S(═O)₂OH.
 5. Substituted carboxamide according to claim 1, wherein R¹, R², R³ and R⁴ are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; methyl; ethyl; n-propyl; isopropyl; cyclopropyl; n-butyl; sec-butyl; tert-butyl; CH₂CF₃; C(═O)-methyl; C(═O)-ethyl; C(═O)—OH; C(═O)—O-methyl; C(═O)—O-ethyl; C(═O)—NH₂; C(═O)—N(methyl)₂; C(═O)—N(ethyl)₂; C(═O)—NH-methyl; C(═O)—NH-ethyl; C(═O)—N(methyl)(ethyl)OH; O-methyl; O-ethyl; O—(CH₂)₂—O—CH₃; O—(CH₂)₂—OH; OCF₃; O—C(═O)-methyl; O—C(═O)-ethyl; NR^(a)R^(b), wherein R^(a) and R^(b) are selected independently of each other from the group consisting of H, methyl, ethyl, (CH₂)₂—O—CH₃ and (CH₂)₂—OH or R^(a) and R^(b) together with the nitrogen atom linking them form a pyrrolidinyl, piperidinyl, 4-methylpiperazinyl or morpholinyl; NHC(═O)-methyl; NHC(═O)-ethyl; SH; SCF₃; S-methyl; S-ethyl; S(═O)₂OH; S(═O)₂O-methyl; benzyl, phenyl, pyridyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, CN, methyl, ethyl, CF₃, OH, O-methyl and OCF₃.
 6. Substituted carboxamide according to claim 1, wherein R⁵ is selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; methyl; ethyl; n-propyl; isopropyl; cyclopropyl; n-butyl; sec-butyl; tert-butyl; CH₂CF₃; C(═O)-methyl; C(═O)-ethyl; C(═O)—OH; C(═O)—O-methyl; C(═O)—O-ethyl; C(═O)—NH₂; C(═O)—N(methyl)₂; C(═O)—N(ethyl)₂; C(═O)—NH-methyl; C(═O)—NH-ethyl; C(═O)—N(methyl)(ethyl)O-methyl; O-ethyl; O—(CH₂)₂—O—CH₃; O—(CH₂)₂—OH; OCF₃; O—C(═O)-methyl; O—C(═O)-ethyl; NR^(a)R^(b), wherein R^(a) and R^(b) are selected independently of each other from the group consisting of H, methyl, ethyl, (CH₂)₂—O—CH₃, (CH₂)₂—OH, C(═O)-methyl, C(═O)-ethyl or R^(a) and R^(b) together with the nitrogen atom linking them form a pyrrolidinyl, piperidinyl, 4-methylpiperazinyl or morpholinyl; SH; SCF₃; S-methyl; S-ethyl; S(═O)₂OH; S(═O)₂O-methyl; benzyl, unsubstituted or mono-, di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, CN, methyl, ethyl, CF₃, OH, O-methyl and OCF₃.
 7. Substituted carboxamide according to claim 1, wherein R⁶ stands for the substructure (T1)

wherein R^(8a) and R^(8b) stand independently of each other for H; F; Cl; Br; I; NO₂; CF₃; CN; OH; OCF₃; NH₂; C₁₋₄ alkyl, O—C₁₋₄ alkyl, NH—C₁₋₄ alkyl, N(C₁₋₄ alkyl)₂, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₄ alkyl, OH and OCF₃; C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₄ alkyl, OH, ═O, O—C₁₋₄ alkyl, OCF₃, NH₂, NH—C₁₋₄ alkyl and N(C₁₋₄ alkyl)₂; m stands for 0, 1, 2, 3 or 4; Y stands for O or NR⁹, wherein R⁹ stands for H; C₁₋₄ alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₄ alkyl, OH, O—C₁₋₄ alkyl, OCF₃, NH₂, NH—C₁₋₄ alkyl and N(C₁₋₄ alkyl)₂; or for C₃₋₁₀ cycloalkyl, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₄ alkyl, OH, O—C₁₋₄ alkyl, OCF₃, NH₂, NH—C₁₋₄ alkyl and N(C₁₋₄ alkyl)₂; n stands for 0 or 1, with the proviso that n does not stand for 1 if m denotes 0; A stands for C₁₋₈ alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, ═O, O—C₁₋₄ alkyl, OCF₃, C(═O)—OH, CF₃, NH₂, NH(C₁₋₄ alkyl), N(C₁₋₄ alkyl)₂, SH, S—C₁₋₄ alkyl, SCF₃ and S(═O)₂OH; C₃₋₁₀ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or, mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃ and S(═O)₂OH; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl and thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃ and S(═O)₂OH.
 8. Substituted carboxamide according to claim 7, wherein R^(8a) and R^(8b) stand independently of each other for H; F; Cl; Br; I; NO₂; CF₃; CN; methyl; ethyl; n-propyl; isopropyl; cyclopropyl; n-butyl; sec-butyl; tert-butyl; CH₂CF₃; OH; O-methyl; O-ethyl; O—(CH₂)₂—O—CH₃; O—(CH₂)₂—OH; OCF₃; NH₂; NH-methyl; N(methyl)₂; NH-ethyl; N(ethyl)₂; or N(methyl)(ethyl); m stands for 1, 2 or 3; n stands for 0; A stands for C₁₋₄ alkyl, saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, OH, O—C₁₋₄ alkyl, OCF₃ and CF₃; C₃₋₁₀ cycloalkyl, saturated, unsubstituted; phenyl, naphthyl, pyridyl, thienyl, each unsubstituted or mono- or di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₄ alkyl, OCF₃, C₁₋₄ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₄ alkyl), N(C₁₋₄ alkyl)₂, SH, S—C₁₋₄ alkyl, SCF₃, and S(═O)₂OH.
 9. Substituted arboxamide according to claim 1, wherein R⁷ is selected from the group consisting of methyl, ethyl, n-propyl, isopropyl, n-butyl, 2-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, n-hexyl, cyclopropyl; cyclobutyl, cyclopentyl, cyclohexyl, methyl cyclopropyl, methyl cyclobutyl, methyl cyclopentyl, methyl cyclohexyl, ethyl cyclopropyl, ethyl cyclobutyl, ethyl cyclopentyl, and ethyl cyclohexyl, each unsubstituted or mono- or polysubstituted with one or more substituents selected from the group consisting of F, Cl, Br, I, OCF₃, SCF₃, CF₃ and OC₁₋₈ alkyl; or phenyl, benzyl or phenethyl, each unsubstituted or mono- or polysubstituted with one or more substituents selected from the group consisting of F, Cl, Br, I, OCF₃, SCF₃, CF₃, C₁₋₈ alkyl, OC₁₋₈ alkyl and CN.
 10. Substituted carboxamide according to claim 1, wherein R¹, R², R³ and R⁴ are each selected independently of one another from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; methyl; ethyl; C(═O)-methyl; OH; O-methyl; O—(CH₂)₂—O—CH₃; OCF₃; O—C(═O)-methyl; NH₂; NH—C(═O)-methyl; N(methyl)₂; morpholinyl; S-methyl; SCF₃; benzyl and phenyl, each unsubstituted; R⁵ is selected from the group consisting of H; F; Cl; Br; I; NO₂; CF₃; CN; methyl; ethyl; C(═O)-methyl; O-methyl; O—(CH₂)₂—O—CH₃; OCF₃; O—C(═O)-methyl; NH₂; NH—C(═O)-methyl; N(methyl)₂; morpholinyl; S-methyl; SCF₃; benzyl, unsubstituted; R⁶ stands for the substructure (T1-1)

wherein R^(8a) and R^(8b) stand independently of each other for H; F; Cl; Br; I; methyl; ethyl; n-propyl; isopropyl; n-butyl; sec-butyl; tert-butyl; OH; O-methyl; O-ethyl; O—(CH₂)₂—O—CH₃; or O—(CH₂)₂—OH; m stands for 1, 2 or 3; A stands for methyl; ethyl; n-propyl; isopropyl; n-butyl; sec-butyl; tert-butyl; cyclopropyl; cyclobutyl; cyclopentyl; cyclohexyl; cycloheptyl; adamantyl; bicyclo[2.2.1]heptyl; bicyclo[2.2.2]octyl; phenyl, pyridyl, thienyl, each unsubstituted or mono-, di- or trisubstituted with one, two or three substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₄ alkyl, OCF₃, C₁₋₄ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₄ alkyl), N(C₁₋₄ alkyl)₂, SH, S—C₁₋₄ alkyl, SCF₃ and S(═O)₂OH; R⁷ stands for C₁₋₈ alkyl or C₂₋₈ heteroalkyl, each saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₈ cycloalkyl or heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃, and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂; C₃₋₈ cycloalkyl or heterocyclyl or C₁₋₆ alkyl- or C₂₋₆ heteroalkyl-bridged C₃₋₈ cycloalkyl or heterocyclyl, each saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, ═O, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl, thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, and S(═O)₂OH; and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₈ cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃; and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂; aryl or heteroaryl or C₁₋₆ alkyl- or C₂₋₆ heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃, S(═O)₂OH, benzyl, phenyl, pyridyl, thienyl, wherein benzyl, phenyl, pyridyl, thienyl can each be unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, C(═O)—OH, CF₃, NH₂, NH(C₁₋₈ alkyl), N(C₁₋₈ alkyl)₂, SH, S—C₁₋₈ alkyl, SCF₃ and S(═O)₂OH; and wherein optionally the alkyl chain or heteroalkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, NO₂, CF₃, CN, OH, ═O, C(═O)—OH, OCF₃, NH₂, S(═O)₂OH, SH, SCF₃, C₁₋₈ alkyl, O—C₁₋₈ alkyl, S—C₁₋₈ alkyl, NH—C₁₋₈ alkyl, N(C₁₋₈ alkyl)₂, C₃₋₁₀ cycloalkyl and heterocyclyl, wherein the aforementioned alkyl radicals can each be saturated or unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, O—C₁₋₈ alkyl, OH and OCF₃; and wherein the aforementioned C₃₋₁₀ cycloalkyl or heterocyclyl can be saturated or unsaturated, unsubstituted or mono- or polysubstituted with one or more substituents each selected independently of one another from the group consisting of F, Cl, Br, I, C₁₋₈ alkyl, OH, ═O, O—C₁₋₈ alkyl, OCF₃, NH₂, NH—C₁₋₈ alkyl and N(C₁₋₈ alkyl)₂.
 11. Substituted carboxamide according to claim 1, wherein R¹, R², R³ and R⁴ each denote independently of one another H; F; Cl; Br; I; CF₃; OH; OCF₃; NH₂; SH; SCF₃; C₁₋₈ alkyl, or O—C₁₋₈ alkyl, each saturated or unsaturated, branched or unbranched, unsubstituted; R⁵ stands for H; F; Cl; Br; I; CF₃; OCF₃; NH₂; SH; SCF₃; C₁₋₈ alkyl, or O—C₁₋₈ alkyl, each saturated or unsaturated, branched or unbranched, unsubstituted; R⁶ stands for C₁₋₈ alkyl or C₂₋₈ heteroalkyl, each saturated, unsaturated, branched or unbranched, unsubstituted; C₃₋₁₀ cycloalkyl, saturated or unsaturated, unsubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, CF₃, SH, S—C₁₋₈ alkyl, SCF₃; C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged C₃₋₁₀ cycloalkyl, saturated or unsaturated, unsubstituted; or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, CF₃, SH, S—C₁₋₈ alkyl, and SCF₃, wherein the alkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted; R⁷ stands for C₁₋₈ alkyl or C₂₋₈ heteroalkyl, each saturated, unsaturated, branched or unbranched, unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, OH, ═O, O—C₁₋₈ alkyl; C₃₋₁₀ cycloalkyl, saturated or unsaturated, unsubstituted; aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, CF₃, SCF₃; C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged C₃₋₁₀ cycloalkyl, saturated or unsaturated, unsubstituted, wherein the alkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted; or C₁₋₈ alkyl- or C₂₋₈ heteroalkyl-bridged aryl or heteroaryl, each unsubstituted or mono- or polysubstituted with one or more substituents selected independently of one another from the group consisting of F, Cl, Br, I, OH, O—C₁₋₈ alkyl, OCF₃, C₁₋₈ alkyl, CF₃, and SCF₃, wherein the alkyl chain can be branched or unbranched, saturated or unsaturated, unsubstituted.
 12. Substituted carboxamide according to claim 1, wherein R¹, R², R³ and R⁴ are each selected independently of one another from the group consisting of H, F, Cl, CF₃ and OCF₃; R⁵ stands for methyl, OMe or —CH₂O-methyl; R⁶ stands for the following substructure (T1)

wherein R^(8a) and R^(8b) stand independently of each other for H, m stands for 1, n for 0 and A stands for phenyl, pyridyl or thienyl, each substituted 0, 1, 2 or 3 times with a substituent selected from the group consisting of F, Cl, Br, I, NO₂, CN, OH, O—C₁₋₄ alkyl, OCF₃, C₁₋₄ alkyl, C(═O)—OH, CF₃, NH₂, NH(C_(IA) alkyl), N(C₁₋₄ alkyl)₂, SH, S—C₁₋₄ alkyl, SCF₃ and S(═O)₂OH, and R⁷ stands for methyl, ethyl, isopropyl, tert-butyl or cyclopropyl.
 13. Substituted carboxamide according to claim 1, selected from the group consisting of: 1 2-(Pentylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide; 2 3-[[3[Oxo-(2-thienylmethylamino)methyl]quinolyl]thio]propanoic acid methyl ester; 3 2-(3-Cyclohexylpropylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide; 4 2-(3-Phenylpropylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide; 5 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienyl-methyl)-3-quinoline carboxamide; 6 2-[3-(4-Fluorophenyl)propylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide; 7 2-(Ethylthio)-N-(2-thienylmethyl)-3-quinoline carboxamide; 8 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienyl-methyl)-6-(trifluoromethyl)-3-quinoline carboxamide; 9 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienylmethyl)-7-(trifluoromethyl)-3-quinoline carboxamide; 10 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-thienylmethyl)-5-(trifluoromethyl)-3-quinoline carboxamide; 11 2-(Pentylthio)-N-(2-thienylmethyl)-6-(trifluoromethyl)-3-quinoline carboxamide; 12 2-(Ethylthio)-N-(2-thienylmethyl)-6-(trifluoromethyl)-3-quinoline carboxamide; 13 N-(2-Thienylmethyl)-2-[2-[3-(trifluoromethyl)-phenyl]sulfonylethylthio]-3-quinoline carboxamide; 14 2-(Ethylthio)-N-(2-thienylmethyl)-7-(trifluoromethyl)-3-quinoline carboxamide; 15 2-(Pentylthio)-N-(2-thienylmethyl)-7-(trifluoromethyl)-3-quinoline carboxamide; 16 2-[2-(4-Fluorophenyl)sulfonylethylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide; 17 2-[2-(p-Tolylsulfonyl)ethylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide; 18 2-[2-(p-Tolylthio)ethylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide; 19 2-[2-(Phenylsulfonyl)ethylthio]-N-(cyclohexylmethyl)-3-quinoline carboxamide; 20 2-[3-(p-Tolyl)propylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide; 21 2-[2-(Phenylthio)ethylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide; 22 2-[2-(Phenylsulfonyl)ethylthio]-N-(2-cyclohexylethyl)-3-quinoline carboxamide; 23 2-[2-(Phenylsulfonyl)ethylthio]-N-(3,3-dimethylbutyl)-3-quinoline carboxamide; 24 2-[2-[(4-Fluorophenyl)thio]ethylthio]-N-(2-thienylmethyl)-3-quinoline carboxamide; 25 N-(3,3-Dimethylbutyl)-2-(ethylthio)-4-methyl-7-(trifluoromethyl)-3-quinoline carboxamide; 26 3-(3-(Thiophen-2-ylmethylcarbamoyl)-6-(trifluoromethyl)quinolin-2-ylthio)propanoic acid methyl ester; 27 3-(3-(Thiophen-2-ylmethylcarbamoyl)-7-(trifluoromethyl)quinolin-2-ylthio)propanoic acid methyl ester; 28 N-(2,2-Dimethylpropyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 29 N-(Cycloheptylmethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 31 N-[(3,4-Difluorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 32 N-[(2,4-Difluorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 33 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[(3,4,5-trifluorophenyl)-methyl]-quinoline-3-carboxamide; 34 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[(2,4,5-trifluorophenyl)-methyl]-quinoline-3-carboxamide; 35 2-Ethylsulfanyl-4-methyl-N-(pyridin-4-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 36 N-[(4-tert-Butylphenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 37 2-Ethylsulfanyl-4-methyl-N-(3-methylbutyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 38 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[[3-(trifluoromethyl)phenyl]-methyl]-quinoline-3-carboxamide; 39 2-Ethylsulfanyl-4-methyl-N-phenethyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 40 2-Ethylsulfanyl-4-methyl-N-(3-phenylpropyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 41 2-Ethylsulfanyl-4-methyl-N-(pyridin-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 42 2-Ethylsulfanyl-4-methyl-N-(pyridin-3-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 43 2-Ethylsulfanyl-4-methyl-N-(naphthalen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 44 2-Ethylsulfanyl-4-methyl-N-(thiazol-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 45 2-Ethylsulfanyl-4-methyl-N-([1,3,4]oxadiazol-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 47 N-[(3-Fluorophenyl)-methyl]-2-(isopropylsulfanyl)-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 48 2-(Cyclopentylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 49 2-(Butylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 50 N-[(3-Fluorophenyl)-methyl]-4-methyl-2-(pentylsulfanyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 51 N-[(3-Fluorophenyl)-methyl]-4-methyl-2-(1-methyl-propylsulfanyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 52 2-(Cyclohexylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 53 N-(2-Cyclopentylethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 54 N-(3-Cyclopentylpropyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 55 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[[4-(trifluoromethyl)phenyl]-methyl]-quinoline-3-carboxamide; 56 N-[(3-tert-Butylphenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 57 2-Ethylsulfanyl-4-methyl-N-(4-methylpentyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 58 2-Benzylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 59 2-Ethylsulfanyl-N-[(3-fluoro-2-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 60 2-Ethylsulfanyl-N-[(5-fluoro-2-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 61 N-[(3,4-Dimethylphenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 62 2-Ethylsulfanyl-4-methyl-7-(trifluoromethyl)-N-[[4-(trifluoromethylsulfanyl)-phenyl]-methyl]-quinoline-3-carboxamide; 63 N-(Cyclohexylmethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 64 2-Ethylsulfanyl-4-methyl-N-(tetrahydropyran-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 65 2-Ethylsulfanyl-4-methyl-N-propyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 66 N-Butyl-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 67 2-Ethylsulfanyl-N-(2-methoxyethyl)-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 68 2-Ethylsulfanyl-4-methyl-N-pentyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 69 2-Ethylsulfanyl-4-methyl-N-[(5-methylthiophen-2-yl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide; 70 2-Ethylsulfanyl-4-methyl-N-[(4-methylthiophen-2-yl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide; 71 N-[(5-Chlorothiophen-2-yl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 72 2-Ethylsulfanyl-4-methyl-N-(2-thiophen-2-yl-ethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 73 N-(5-Bicyclo[2.2.1]heptanylmethyl)-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 74 N-Benzyl-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 75 2-Ethylsulfanyl-N-[(2-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 76 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 77 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 78 N-[(2-Chlorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 79 N-[(3-Chlorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 80 N-[(4-Chlorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 81 2-Ethylsulfanyl-4-methyl-N-(o-tolylmethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 82 2-Ethylsulfanyl-4-methyl-N-(m-tolylmethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 83 2-Ethylsulfanyl-4-methyl-N-(p-tolylmethyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 84 2-Ethylsulfanyl-N-[(2-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 85 2-Ethylsulfanyl-N-[(3-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 86 2-Ethylsulfanyl-N-[(4-methoxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 87 N-[(3,5-Difluorophenyl)-methyl]-2-ethylsulfanyl-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 88 4-Methyl-2-methylsulfanyl-N-(thiophen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 89 2-(tert-Butylsulfanyl)-4-methyl-N-(thiophen-2-yl-methyl)-7-(trifluoromethyl)-quinoline-3-carboxamide; 90 N-(2,2-Dimethylpropyl)-2-ethylsulfanyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 91 2-Ethylsulfanyl-4-methyl-N-(thiophen-2-yl-methyl)-quinoline-3-carboxamide; 92 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 93 2-(tert-Butylsulfanyl)-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 94 2-(tert-Butylsulfanyl)-N-[(4-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 95 7-tert-Butyl-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 96 7-tert-Butyl-2-ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 97 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-methoxy-4-methyl-quinoline-3-carboxamide; 98 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-7-methoxy-4-methyl-quinoline-3-carboxamide; 99 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4,6-dimethyl-quinoline-3-carboxamide; 100 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4,6-dimethyl-quinoline-3-carboxamide; 101 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-6-methoxy-4-methyl-quinoline-3-carboxamide; 102 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-6-methoxy-4-methyl-quinoline-3-carboxamide; 103 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-6-(trifluoromethyl)-quinoline-3-carboxamide; 104 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-6-(trifluoromethyl)-quinoline-3-carboxamide; 105 2-Ethylsulfanyl-7-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 106 2-Ethylsulfanyl-7-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 107 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4,7-dimethyl-quinoline-3-carboxamide; 108 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4,7-dimethyl-quinoline-3-carboxamide; 109 2-Ethylsulfanyl-6,7-difluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 110 2-Ethylsulfanyl-N-(furan-2-yl-methyl)-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 111 2-Ethylsulfanyl-4-methyl-N-[(5-methyl-furan-2-yl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide; 113 2-Ethylsulfanyl-N-[(3-hydroxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 114 N-[(3-Fluorophenyl)-methyl]-4-methyl-2-methylsulfanyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 115 N-[(4-Fluorophenyl)-methyl]-4-methyl-2-methylsulfanyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 116 2-Ethylsulfanyl-6-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 117 2-Ethylsulfanyl-6-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 118 2-Ethylsulfanyl-6,7-difluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 119 2-Ethylsulfanyl-N-[(4-hydroxyphenyl)-methyl]-4-methyl-7-(trifluoromethyl)-quinoline-3-carboxamide; 120 2-Ethylsulfanyl-8-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 121 2-Ethylsulfanyl-8-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 123 2-Ethylsulfanyl-5-fluoro-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 124 2-Ethylsulfanyl-5-fluoro-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 125 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-5-methoxy-4-methyl-quinoline-3-carboxamide; 126 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-5-methoxy-4-methyl-quinoline-3-carboxamide; 127 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-5-hydroxy-4-methyl-quinoline-3-carboxamide; 128 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-6-hydroxy-4-methyl-quinoline-3-carboxamide; 129 2-Ethylsulfanyl-N[(3-fluorophenyl)-methyl]-7-hydroxy-4-methyl-quinoline-3-carboxamide; 133 7-Dimethylamino-2-ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 134 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-morpholin-4-yl-quinoline-3-carboxamide; 135 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-7-morpholin-4-yl-quinoline-3-carboxamide; 136 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-8-(trifluoromethyl)-quinoline-3-carboxamide; 137 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-4-methyl-8-(trifluoromethyl)-quinoline-3-carboxamide; 138 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-8-methoxy-4-methyl-quinoline-3-carboxamide; 139 2-Ethylsulfanyl-N-[(4-fluorophenyl)-methyl]-8-methoxy-4-methyl-quinoline-3-carboxamide; 140 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-8-hydroxy-4-methyl-quinoline-3-carboxamide; 141 7-Dimethylamino-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-quinoline-3-carboxamide; 142 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-methyl-7-(trifluoromethyloxy)-quinoline-3-carboxamide; 143 4-Ethyl-2-ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-7-(trifluoromethyl)-quinoline-3-carboxamide; 144 2-Ethylsulfanyl-N-[(3-fluorophenyl)-methyl]-4-isopropyl-7-(trifluoromethyl)-quinoline-3-carboxamide; and the physiologically compatible salts thereof.
 14. A pharmaceutical composition comprising at least one substituted carboxamide according to claim 1 or the compound N-benzyl-2-(3-chloro-2-hydroxypropylthio)-4-(2,4-dichlorophenyl)quinoline-3-carboxamide, in the form of an individual stereoisomer or a mixture thereof, in the form of a free compound and/or a physiologically compatible thereof, and optionally one or more suitable additives and/or auxiliary substances and/or optionally further active ingredients.
 15. A method of treating a disorder in a patient in need of such treatment, said disorder being at least one disorder selected from the group consisting of pain, epilepsy, urinary incontinence, anxiety states, dependency, mania, bipolar disorders, migraine, cognitive diseases, and dystonia-associated dyskinesias, said method comprising administering to said patient an amount effective to treat said disorder of at least one substituted carboxamide according to claim 1 or the compound N-benzyl-2-(3-chloro-2-hydroxypropylthio)-4-(2,4-dichlorophenyl)quinoline-3-carboxamide, each in the form of an individual stereoisomer or a mixture thereof, in the form of a free compound and/or a physiologically compatible salt thereof.
 16. (canceled) 